TY  - JOUR
T1  - Intralesional application of epidermal growth factor in limb-threatening ischemic diabetic foot ulcers
AU  - Aktaş, Şamil
AU  - Baktıroğlu, Selçuk
AU  - Demir, Levent
AU  - Kılıçoğlu, Önder
AU  - Topalan, Murat
AU  - Güven, Erdem
AU  - Mirasoğlu, Bengüsu
AU  - Yanar, Fatih
PY  - 2016
DA  - April
JF  - Acta Orthopaedica et Traumatologica Turcica
PB  - Turkish Association of Orthopaedics and Traumatology
WT  - DergiPark
SN  - 1017-995X
SP  - 277
VL  - 50
IS  - 3
LA  - en
AB  - Objective: The intralesional injection of recombinant human epidermal growth factor (EGF-IL), a new therapy, has been claimed to prevent major amputations in advanced diabetic foot lesions. In this study, the efficacy of EGF-IL on advanced diabetic foot ulcers (DFU) was reviewed.Methods: Intralesional 75 μg EGF application (Heberprot-P® 75, Heber Biotec, Havana, Cuba) to 12 diabetic foot lesions in 11 patients (8 males, 3 females; mean age: 62.2±10.6 years) was evaluated. Most of the patients had undergone revascularization and received hyperbaric oxygen therapy (HBOT) and negative pressure wound therapy (NPWT), along with standard care, but failed to heal. After amputation was offered as the final option, EGF-IL was applied to evaluate its effects.Results: Two patients underwent amputation, while 10 lesions of the remaining 9 patients healed completely.Conclusion: Our results prove that intralesional application of EGF can prevent amputations in advanced diabetic foot cases with an ischemic component. However, evidence in the literature supporting its use remains lacking, and its high cost presents an additional problem. Thus, we believe that intralesional application of EGF should be an option for ischemic wounds only after vascular evaluation (and intervention when possible), HBOT, NPWT, and standard care have proven insufficient.
KW  - Diabetic foot ulcer; epidermal growth factor; leg amputation.
UR  - https://dergipark.org.tr/en/pub/aott/article/192565
L1  - https://dergipark.org.tr/en/download/article-file/170836
ER  -