@article{article_192612, title={EFFECTS OF IMMOBILIZATION AND WHOLE-BODY VIBRATION ON RAT SERUM TYPE I COLLAGEN TURNOVER}, journal={Acta Orthopaedica et Traumatologica Turcica}, year={2016}, author={Donmez, Gurhan and Doral, Mahmut and Doral, Mahmut and Suljevic, Şenay and Suljevic, Şenay and Sargon, Mustafa and Sargon, Mustafa and Bilgili, Hasan and Bilgili, Hasan and Demirel, Haydar and et al.}, keywords={Immobilization;rehabilitation;whole-body vibration;collagen;PINP;CTX}, abstract={<p>Objectives:Despite documentation of the detrimental effects of immobilization on the musculoskeletal system, immobilization is still a frequently applied treatment method for several sports injuries. This study was designed to investigate the effects of short-term, high-magnitude whole-body vibration (WBV) on serum type I collagen turnover in immobilized rats. <br /> <br /> Materials and Methods:Thirty Wistar albino rats were randomly divided into the following 5 groups: immobilization(IS), immobilization + remobilization(IR), immobilization + WBV(IV), control(C), and WBV control(CV). Immobilization was achieved by casting from the crista iliaca anterior superior to the lower part of the foot for 2 weeks. The applied WBV protocol involved a frequency of 45 Hz and amplitude of 3 mm for 7 days starting a day after the end of the immobilization period. Serum type I collagen turnover markers were measured by using ELISA kits. <br /> <br /> Results:Serum NH2-terminal propeptide of type I collagen (PINP) levels were significantly lower in the immobilization groups (p < 0.02) compared with the control groups. Although WBV improved PINP levels in the control groups, there were no differences in PINP levels among the immobilization groups. Similarly, serum COOH-terminal telopeptide of type I collagen (CTX) levels were higher in the WBV controls than their own controls (p<0,05). Immobilization led to deterioration of tendon tissue, as observed by histopathological analysis with a transmission electron microscope. <br /> <br /> Conclusion:Although 1 week of WBV had a positive effect on type I collagen turnover in controls, it is not an efficient method for repairing tissue damage in the early stage following immobilization. </p> <p>  </p> <p>DOI: 10.3944/AOTT.2016.15.0353 <br />This abstract belongs to the un-edited version of the article and is only for informative purposes. Published version may differ from the current version. </p>}, publisher={Turkish Association of Orthopaedics and Traumatology}