TY  - JOUR
T1  - Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism
AU  - Uçar, Fatma
AU  - Akyol, Sümeyya
AU  - Ozturk, Gulfer
AU  - Gınıs, Zeynep
AU  - Erden, Gonul
AU  - Taspınar, Mine
AU  - Arzuhal, Abdullah
AU  - Delıbası, Tuncay
PY  - 2014
DA  - September
JF  - Deneysel ve Klinik Tıp Dergisi
JO  - J. Exp. Clin. Med.
PB  - Ondokuz Mayıs University
WT  - DergiPark
SN  - 1309-4483
SP  - 77
EP  - 80
VL  - 31
IS  - 2
LA  - en
AB  - Increasing numbers of researches have indicated the relationship between serum vitaminD level and several autoimmune diseases, because it has important roles in immuneregulation. However, the role of vitamin D in the etiopathogenesis of these diseases isnot well understood. Similarly, the detailed mechanism of vitamin D action on thyroidhormone metabolism and autoimmune thyroid diseases is still poorly understood. It wasrecently reported that patients with autoimmune thyroid disease showed lower vitamin Dlevels. However, there are few studies dealing with vitamin D status in elderly patientswith subclinical hypothyroidism. We therefore aimed to investigate vitamin D levels inelderly patients with subclinical hypothyroidism. In the present study, a total of 37 patients(>70 years old) with subclinical hypothyroidism and 40 healthy controls (>70 years old)were retrospectively analyzed. Serum levels of free triiodothyronine (fT3), free thyroxine(fT4) and thyroid-stimulating hormone (TSH) were analyzed by chemiluminescenceimmunoassay (Centaur XP, Siemens Healthcare Diagnostics Inc., Tarrytown, USA).Serum levels of 25-Hydroxy vitamin D (25-OH D) were measured by chemiluminescenceimmunoassay (DiaSorin, Liaison, Italy). Serum anti thyroid peroxidase (anti-TPO)and anti thyroglobulin (anti-TG) were measured using a solid-phase, enzyme-labeled,chemiluminenescent sequential immunometric assay (Immulite 2000 XPi, SiemensHealthcare Diagnostics Inc., Tarrytown, USA). There was no significant differencebetween groups in terms of age and gender distribution. Serum TSH, anti-TPO and anti-TG levels in elderly patients with subclinical hypothyroidism showed higher values thanhealthy controls as expected. Serum 25-OH D levels in elderly patients with subclinicalhypothyroidism were lower than healthy controls (p<0.001). These data may suggestassociation between serum 25-OH D levels and subclinical hypothyroidism in elderlypatients. Further studies are needed to determine whether vitamin D insufficiency is acasual factor in the etiopathogenesis of subclinical hypothyroidism in elderly patients orrather a consequence of the disease.
KW  - Autoantibodies
KW  - Elderly
KW  - Subclinical hypothyroidism
KW  - Vitamin D
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UR  - https://dergipark.org.tr/en/pub/omujecm/article/217502
L1  - https://dergipark.org.tr/en/download/article-file/190385
ER  -