TY  - JOUR
T1  - The rates of eNOS Glu298Asp gene polymorphism among psoriatic patients in Çanakkale, Turkey
AU  - Hız, Meliha Merve
AU  - Öğretmen, Zerrin
AU  - Sılan, Fatma
AU  - Özdemir, Öztürk
PY  - 2014
DA  - September
DO  - 10.5835/jecm.v2i31.5000068739
JF  - Deneysel ve Klinik Tıp Dergisi
JO  - J. Exp. Clin. Med.
PB  - Ondokuz Mayıs University
WT  - DergiPark
SN  - 1309-4483
SP  - 0
VL  - 31
IS  - 2
LA  - en
AB  - Psoriasis is a complex immunological disease with several comorbidities. Thus severalgenes related to immun system was recognized as disease susceptibility genes. On theother hand, the conserved mechanism that triggers both psoriasis and comorbidities areimportant to identify the common physiology of diseases. Thus, in this study, the prevalenceand distribution of the eNOS Glu298Asp polymorphism among psoriatic patientswere evaluated. 114 psoriatic patients, who gave informed consent, were enrolled in thestudy. The genotype frequencies for eNOS gene polymorphism were determined by meltingcurve analyses (Real time PCR). In consistency of genotype frequencies (biallelicmarkers) with the Hardy-Weinberg equilibrium was tested using a Chi-Square test on acontingency table of observed versus predicted genotype frequencies. Sixty two patients(54.4%) had the genotype Glu/Glu (wild group) and 52 (45.6%) patients a mutant genotype,Glu/Asp (46 patients, 40.4%) or Asp/Asp (6 patients, 5.2%). The genotype distributionwere consistent with Hardy-Weinberg equilibrium for psoriatic groups (χ²calculate: 0,496 1st degree). We could not found any differences between allelic distribution orgenotype frequency of eNOS Glu298Asp gene polymorphism and psoriasis.
KW  - eNOS; Glu298Asp; polymorphism; psoriasis
UR  - https://doi.org/10.5835/jecm.v2i31.5000068739
L1  - https://dergipark.org.tr/en/download/article-file/190405
ER  -