TY  - JOUR
T1  - Effect of Urtica dioica extract on stereological structure of ventral prostate in streptozotocin induced diabetic rats
AU  - Hamıdıan, Gholamreza
AU  - Zangısheh, Mahsa
PY  - 2014
DA  - September
DO  - 10.5835/jecm.v2i31.5000068743
JF  - Deneysel ve Klinik Tıp Dergisi
JO  - J. Exp. Clin. Med.
PB  - Ondokuz Mayıs University
WT  - DergiPark
SN  - 1309-4483
SP  - 0
VL  - 31
IS  - 2
LA  - en
AB  - Diabetes mellitus is a common and important metabolic disorder that can be associatedwith many functional and structural complications in male sex organs and infertility.Many studies showed that Urtica dioica caused hypoglycemia and prevented diabetesundesirable side effects on the different organs. This study was done to investigate theeffects of ethanol extract of Urtica dioica on ventral prostate in streptozotocin induceddiabetic rats. In this study, 15 adult male wistar rats were divided into control, diabeticand treatment groups. Hyperglycemia was induced by 50 mg/kg Streptozotocin (STZ) indiabetic and treatment groups. One week after STZ injection, treatment group received30 mg/kg/day Urtica dioica extract by oral gavage for 30 consecutive days. Finally animalswere euthanized and ventral prostate were removed and fixed in 10% neutral bufferedformalin. Samples of the ventral prostate were obtained according to the orientatorto produce an isotropic uniform random sample. The volumes of the lumen, glandularepithelium and fibromuscular stroma were estimated by multiplying each respective volumedensity. This study showed that diabetes could lead to structural changes in ventralprostate. Stereological results indicated that volume of lumen and fibromuscular stromaof ventral prostate was significantly increased in diabetic rats but Urtica dioica could inhibitthese changes partially. It was also revealed that volume of glandular epithelium wassignificantly reduced in ventral prostate of diabetic rats but it was significantly increasedin treated animals compared to diabetic animals (p<0.05). It can be concluded that administrationof ethanolic extract of Urtica dioicaa can inhibit side effect of diabetes onstructure of ventral prostate and has protective effects on its histoarchitecture.
KW  - Diabetes; stereology; Urtica dioica; ventral prostate
UR  - https://doi.org/10.5835/jecm.v2i31.5000068743
L1  - https://dergipark.org.tr/en/download/article-file/190409
ER  -