TY - JOUR T1 - Astımlı çocuklarda inhale budesonid tedavisinin kemik dansitesi üzerine etkisi TT - Effect of inhaled budesonide treatment on bone density in children with asthma AU - Yılmaz, Serdar AU - Tokuç, Gülnur AU - Öktem, Sedat AU - Girit, Nadir PY - 2005 DA - May DO - 10.16948/zktb.37986 JF - Zeynep Kamil Tıp Bülteni PB - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH WT - DergiPark SN - 1300-7971 SP - 185 EP - 188 VL - 36 IS - 4 LA - tr AB - Amaç: Astımlı çocuklarda inhale budesonid'in kemik dansitesi ve kemik metabolizması üzerine olan etkisini değerlendirmek. Gereç ve Yöntem: Prospektif çalışmamıza, polikliniğimizde astım tanısı ile izlenen 5-14 yaşlar arasındaki çocuklardan 126'sı dahil edildi. Hastalar 6 aydan uzun süre inhale budesonid alan 86 astımlı çocuk (Grup I); ve inhale steroid kullanmayan 40 astımlı çocuk (Grup II) olarak 2 gruba ayrıldı. Hastaların serum Ca, P, ALP ve kemik dansitesi ölçüldü. Bulgular: Çalışılan 2 grubun serum kalsiyum değerleri sırasıyla 9.20.7; 9.70.5 mg/dl, fosfor değerleri 4.21.1; 4.60.8 mg/dl, alkalen fosfataz değerleri 415108; 402112 U/L, kemik dansite değerleri 0.89 0.09; 0.88 0.07 g/cm2 idi. İki grup arasında istatistiksel bir fark saptanmadı. Sonuç: Çalışmamızda ortalama 256102 mcg/gün ve 17.811 ay süre ile kullanılan budesonidin kemik dansitesi üzerine olumsuz etkisi saptanmadı. KW - Budesonid KW - Kemik yoğunluğu KW - Astım KW - Çocuk KW - İleriye dönük çalışma N2 - Objective: To asses the effect of inhaled budesonide on the bone density and bone metabolism in children with asthma. Material and Methods: Prospective study was conducted in 126 children with asthma aged 5 to 14 years, selected from the pediatric outpatient clinic. Two study group were assembled: 86 asthmatic children treated with inhaled budesonide for over 6 months (Group I); and 40 asthmatic children not treated with inhaled corticosteroids (Group II). Serum Ca, P, ALP and bone density was measured. Results: In these two groups studied (I and II) calcium serum levels were 9.20.7; 9.70.5 mg/dl, respectively; phosphorus levels were 4.21.1; 4.60.8 mg/dl, alkaline phosphatase levels were 415108; 402112 U/L, bone density levels were 0.89 0.09; 0.88 0.07 g/cm2, respectively. No statistically significant differences were observed between the two groups. Conclusion: There is no evidence in our study that inhaled budesonide mean 256102 mcg/day and 17.8±11 month duration has an adverse effect on bone density. CR - 1.König P, Hillman LCervente CI. Bone metabolism in children with asthma treated with inhaled beclamethasone dipropionate. J Pediatr 1993; 122:219-26 CR - 2.Boulet LP, Giguera MC, et al. Effects of long term use of high dose inhaled steroids on bone density and calcium metabolism. J Allergy Clin Immun 1994; 94:796-803 CR - 3.Hanania NA, Chapman KR, et al. 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