@article{article_252680, title={Resveratrol Inhibits Palmitic Acid Induced Endoplasmic Reticulum Stres: Anti-Apoptotic Effect}, journal={The Journal of Kırıkkale University Faculty of Medicine}, volume={18}, pages={68–74}, year={2016}, DOI={10.24938/kutfd.252680}, author={Ceylan, Aslı F. and Aslan Erdem, Sinem}, keywords={Apoptosis,endoplasmic reticulum stress,H9c2 cell,palmitic acid,resveratrol}, abstract={<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="652" style="width:488.9pt;margin-left:5.4pt;"> <tbody> <tr> <td width="326" valign="top" style="width:244.45pt;padding:0cm 5.4pt;"> <p class="MsoNoSpacing" style="margin-bottom:3pt;text-align:justify;line-height:115%;"> <b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">  </span> </b> </p> <p class="MsoNoSpacing" style="margin-bottom:3pt;text-align:justify;line-height:115%;"> <b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">Introduction </span> </b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">: </span> <span style="font-size:9pt;line-height:115%;">Endoplasmic reticulum (ER) stress is involved in the pathophysiology of obesity but little is known about the role of ER-stress on obesity-induced cardiovascular diseases. </span> <span lang="en-us" style="font-size:9pt;line-height:115%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNoSpacing" style="margin-bottom:3pt;text-align:justify;line-height:115%;"> <b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">Material and Methods </span> </b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">: </span> <span style="font-size:9pt;line-height:115%;">This study was designed to examine the effect of resveratrol, a natural polyphenolic compound, on palmitic acid-induced ER-stress in H9c2 cell lines. ER-stress was induced by various concentration of PA in different time manner in H9c2 cell lines. Effects of resveratrol on ER-stress and apoptosis pathways were examined in this model. </span> <span lang="en-us" style="font-size:9pt;line-height:115%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNoSpacing" style="margin-bottom:3pt;text-align:justify;line-height:115%;"> <b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">Results </span> </b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">: PA activated ER-stress pathway in a dose- and time-dependent manner. Indeed, apoptotic pathway was activated in the cells by PA. Resveratrol not only alleviated ER-stress but also inhibited apoptosis. On the other hand, PA increased oxidative stress in the cells which was alleviated by resveratrol. </span> <span lang="en-us" style="font-size:9pt;line-height:115%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNoSpacing" style="margin-bottom:3pt;text-align:justify;line-height:115%;"> <b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">Conclusion </span> </b> <span lang="en-gb" style="font-size:9pt;line-height:115%;" xml:lang="en-gb">: </span> <span style="font-size:9pt;line-height:115%;">Our results suggest that, resveratrol play a role in alleviating ER-stress and inhibiting apoptosis in H9c2 cell lines. </span> <span lang="en-us" style="font-size:9pt;line-height:115%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNoSpacing" style="margin-top:0cm;margin-right:-5.55pt;margin-bottom:3pt;margin-left:0cm;text-align:justify;line-height:115%;"> <i> <span style="font-size:9pt;line-height:115%;">  </span> </i> </p> </td> </tr> </tbody> </table>}, number={2}, publisher={Kirikkale University} }