TY  - JOUR
TT  - Investigation of In Vitro Activity of Daptomycin and Some Antibiotics against Staphylococcus Strains Isolated from Blood and Wound Cultures
AU  - Güzel, Mustafa
AU  - Akdoğan, Doğan
PY  - 2016
DA  - September
Y2  - 2016
DO  - 10.21673/anadoluklin.254215
JF  - Anatolian Clinic the Journal of Medical Sciences
JO  - Anatolian Clin
PB  - Hayat Sağlık ve Sosyal Hizmetler Vakfı
WT  - DergiPark
SN  - 2149-5254
SP  - 173
EP  - 177
VL  - 21
IS  - 3
KW  - daptomisin
KW  - duyarlılık
KW  - linezolid
KW  - Staphylococcus aureus
N2  - Aim: Daptomycin is a 13-member amino-acid cyclic lipopeptide and a new antibiotic that hasbeen developed especially for use in the treatment of Gram-positive bacteria. In thisstudyweaimed to determine the level of susceptibility to daptomycin and resistance to some other antibioticsof Staphylococcus strains isolated from blood and wound cultures.Materials and Methods: In this study, the minimal inhibitory concentration (MIC) for daptomycinof thirty methicillin-resistant S. aureus (MRSA), seventy methicillin-susceptible S. aureus(MSSA), fifty methicillin-resistant coagulase-negative staphylococci (MRCNS) and fifty methicillin-susceptible coagulase-negative staphylococci (MSCNS) that were sent from various clinicswas evaluated by the methods of antibiotic gradient andother antimicrobial susceptibilitytesting.Results: All of the strains were found susceptible to daptomycin, vancomycin, and linezolid.Daptomycin MIC50/MIK90 values for the MRSA, MSCNS and MSSA strains were found to be0.064/0.094 μg /ml and MIC50/MIK90 values for the MRCNS strains 0.094/0.25 μg/ml.Discussion and Conclusion: The finding that daptomycin MIC values are in the applicable intervalsuggests that daptomycin can be used as an alternative to glycopeptides and linezolid in theclinic. Development of resistance is preventable when its appropriate use is ensured.
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UR  - https://doi.org/10.21673/anadoluklin.254215
L1  - https://dergipark.org.tr/en/download/article-file/220477
ER  -