@article{article_258992, title={SYNTHESIS AND RADICAL SCAVENGING PROPERTIES OF SELENOPHENYL BENZAMIDE ANOLOGS}, journal={Gazi University Journal of Science}, volume={29}, pages={317–321}, year={2016}, author={Altundas, Aliye and Doğanay, Kadir and Karaaslan, Merve Göksin and Ates, Burhan}, keywords={Selenophene, Selenopheneyl benzamide, Antioxidant activity}, abstract={<p> <span lang="en-us" xml:lang="en-us">Free radicals that result from different kinds of oxidative stress have been concerned in a variety of human disorders, from cardiac ischemia to those affecting the central nervous system. So, there is an increasing interest in the development of antioxidant molecules that can protect cells against free radical damages. Sets of tetrasubstituted selenophene amides <strong>4a-e </strong> were synthesized by reaction of </span> <span lang="en-us" xml:lang="en-us">2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]selenophen-3-carbonitrile </span> <span lang="en-us" xml:lang="en-us"> ( <strong>2) </strong> with benzoyl chloride derivatives and </span> <span lang="en-us" xml:lang="en-us">the structures of the amide derivatives <span>were characterized by </span> </span> <span lang="en-us" xml:lang="en-us">MS, <sup>1 </sup>H-NMR, <sup>13 </sup>C-NMR and IR spectra. <span> The synthesized compounds ( <strong>4a-e </strong>) were evaluated in terms of <em>in vitro </em>. The antioxidant properties were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging properties and IC <sub>50 </sub> values of the compounds were in the range from 3.794 to </span>5.644 mg/mL. <span>Compounds <span class="apple-converted-space">  </span> <strong>4c </strong> <span class="apple-converted-space">  </span>and <span class="apple-converted-space">  </span> <strong>4e </strong> <span class="apple-converted-space">  </span>showed predominant radical scavenging activity among the synthesized analogues. </span> <strong> </strong> </span> </p>}, number={2}, publisher={Gazi University}