TY  - JOUR
TT  - Investigation of oxidative stress index in pyridine and ellagic acid treated mice
AU  - Kaya, İnan
AU  - Deveci, Haci Ahmet
AU  - Karapehlivan, Mahmut
AU  - Kükürt, Abdulsamed
PY  - 2015
DA  - September
JF  - Eurasian Journal of Veterinary Sciences
JO  - Eurasian J Vet Sci
PB  - Selcuk University
WT  - DergiPark
SN  - 1309-6958
SP  - 148
EP  - 151
VL  - 31
IS  - 3
KW  - Fare
KW  - piridin
KW  - paraoksonaz
KW  - oksidatif stres
KW  - ellagik asit
N2  - Aim: In the present study, effect of ellagic acid on levels of paraoxonase (PON1), oxidative stress index (OSI), total antioxidant (TAS) and total oxidant (TOS) in pyridine intoxication was investigated. Material and Methods: In the study, 28 male Swiss albino mice were divided into 4 equal groups as following. Control I (Control group, n:7, 0.9% NaCl, IP, SID, 7 days), Group II was applied with pyridine (n:7, 100 mg/kg, IP, SID, 7 days), Group III was applied with ellagic acid (n:7, 10 mg/kg, SC, SID, 7 days) and Group IV was treated with pyridine (100 mg/kg, IP, SID, 7 days) plus ellagic acid (10 mg/kg, SC, SID, 7 days). Serum PON1 activity, OSI, TAS and TOS levels were determined by spectrophotometric methods at the end of the experiment.Results: OSI and TOS levels significantly increased, whereas serum PON1 activity and TAS levels reduced in pyridine treatment group (Group II) when compared to control group. Conclusion: Ellagic acid may show the protective effects against pyridine-induced oxidative stress.
UR  - https://dergipark.org.tr/en/pub/eurasianjvetsci/issue//262022
L1  - https://dergipark.org.tr/en/download/article-file/228542
ER  -