TY  - JOUR
T1  - TERNARY COMPLEX FORMATION OF ISONIAZID WITH SOME TRANSITION METALS AND AMINO ACIDS
TT  - İSONİAZİD VE BAZI AMİNO ASİTLERİN GEÇİŞ METALLERİ İLE OLUŞTURDUĞU ÜÇLÜ KOMPLEKSLERİN TAYİNİ
AU  - Alkaya, Bilgiç
AU  - Karaderi, Serap
AU  - Erdoğan, Gülbin
PY  - 2016
DA  - April
JF  - Trakya University Journal of Natural Sciences
JO  - Trakya Univ J Nat Sci
PB  - Trakya University
WT  - DergiPark
SN  - 2528-9691
SP  - 1
EP  - 14
VL  - 14
IS  - 1
LA  - en
AB  - In this article mixed ligand complex formation equilibria of copper(II) and zinc(II) withisoniazid and two amino acids have been determined by potentiometric titration method,involving the use of Irving Rossotti procedure. The formation constants of mixed ligandcomplexes have been found to be Cu(II)-isoniazid-L-asparagine logK= 7.29; Zn(II)-isoniazid-L-asparagine logK= 4.09 and Cu(II)-isoniazid-L-glutamic acid logK= 6.70; Zn(II)-isoniazid-L-glutamic acid logK= 6.30, at 25.0±0.1° C and I= 0.11 mol dm-3 ionic strength (NaCIO4) in aqueous solution. The maximum values of the conditional formation constantswere found to be in accordance with the mixed-ligand complex formation constants in a givenpH region. In addition, the mole fractions of different species from mixed complexes werecalculated by means of formation constants.
KW  - Isoniazid
KW  - L-asparagine
KW  - L-glutamic acid
KW  - metal complex
KW  - satibility constant
N2  - Bu çalışmada isoniazid ve iki aminoasitin bakır(II) ve çinko(II) metalleri ile oluşturduğukarışık kompleks oluşum dengeleri Irving Rossotti metodu ile potansiyometrik olarak tayinedildi. Üçlü komplekslerin stabilite sabitleri Irving Rossotti yöntemi ile 25±0.1 ºC de veiyonik kuvvet (0.11M) NaClO4 ile sabit tutularak sulu çözeltide incelendi. 25 ºC de karışıkligand komplekslerin oluşum sabitleri;Cu(II)-isoniazid-L-asparajin logK= 7.29; Zn(II)-isoniazid-L-asparajin logK= 4.09;Cu(II)-isoniazid-L-glutamik asit logK= 6.70; Zn(II)-isoniazid-L-glutamik asit logK= 6.30olarak bulundu. Oluşan komplekslerin koşullu oluşum sabitleri pH’a bağlı olarak hesaplandıve belirli bir pH bölgesinde koşullu oluşum sabitinin maksimum olduğu değerin deneyselolarak bulunan kararlılık sabiti ile uyum içinde olduğu gözlendi. Ayrıca karışık komplekstentüreyen türlerin bağıl bollukları oluşum sabitlerinden hesaplandı.
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UR  - https://dergipark.org.tr/en/pub/trkjnat/issue//267884
L1  - https://dergipark.org.tr/en/download/article-file/234510
ER  -