TY  - JOUR
TT  - OSTEOCALCIN AND OSTEONECTIN EXPRESSION AFTER DOUBLE-APPLICATION OF PLATELET-RICH PLASMA IN RABBITS
AU  - Çakılcı Özdemir, Burcu
AU  - Kurtiş, Bülent
AU  - Tüter, Gülay
AU  - Şengüven, Burcu
AU  - Yıldırım, Benay
AU  - Özcan, Gönen
PY  - 2016
DA  - April
DO  - 10.17096/jiufd.40536
JF  - Journal of Istanbul University Faculty of Dentistry
JO  - J Istanbul Univ Fac Dent
PB  - Istanbul University
WT  - DergiPark
SN  - 2149-4592
SP  - 1
EP  - 9
VL  - 50
IS  - 2
KW  - Platelet-Rich Plasma
KW  - osteonectin; osteocalcin; wound healing; osteogenesis
N2  - Purpose: Platelet-rich plasma (PRP) is a novel method for transferring autogenous growth factors to the wound area. The aim of this study was to evaluate the efficacy of double-application of PRP (DA-PRP) on bone healing in rabbit cranial defects by examining osteonectin (ON) and osteocalcin (OC) expression.Materials and Methods: Twenty-eight rabbits, each with two surgically prepared calvarial bone defects, were included in this study and divided into six groups: The defects (N=56) were treated with either a single-application of PRP (SA-PRP) (n=10), a combination of SA-PRP and betatricalciumphosphate (SA-PRP+β-TCP) (n=10), only DAPRP (n=8), both DA-PRP and beta-tricalciumphosphate (DA-PRP+β-TCP) (n=8), only beta-tricalciumphosphate (β-TCP) (n=10), or controls (n=10). The animals were sacrificed at 30th day postoperatively and samples were immunohistochemically examined for ON and OC expressions.Results: It was determined that DA-PRP did not significantly improve the ON and OC percentages achieved by SA-PRP or the controls. The three groups treated with β-TCP showed a higher percentage of ON than those treated without β-TCP (p<0.05). The β-TCP treated groups and SA-PRP group demonstrated higher OC percentage than DA-PRP and control groups (p<0.05).Conclusion: The present findings suggest that DAPRP did not have a significant effect on the healing of non-critical size rabbit cranial bone defects.
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UR  - https://doi.org/10.17096/jiufd.40536
L1  - https://dergipark.org.tr/en/download/article-file/235372
ER  -