@article{article_268791, title={SERUM TRANSFORMİNG GROWTH FACTOR BETA 1 (TGF-Β1) LEVELS IN PANCREATIC ADENOCARCINOMA PATIENTS}, journal={Journal of Istanbul Faculty of Medicine}, volume={79}, pages={9–15}, year={2016}, DOI={10.18017/iuitfd.78568}, author={Karabulut, Senem and Karabulut, Mehmet and Afşar, Çiğdem Usul and Alış, Halil and Dağoğlu, Nergiz and Akarsu, Cevher and Ertürk, Kayhan and Bilgin, Elif and Taş, Faruk}, keywords={Pancreatic adenocarcinoma,TGF-β1,diagnosis}, abstract={<p class="MsoNormal" style="text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Objective: </span> </b> <span style="font-size:10pt;color:#131413;">The transforming growth factor beta 1 (TGF </span> <span style="font-size:10pt;">- <span style="color:#131413;">β1) is a regulatory
cytokine </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">in many tumors. In this
study, we aimed to determine the clinical significance of serum </span> <span style="font-size:10pt;color:#131413;">TGF- </span> <span style="font-size:10pt;"> <span style="color:#131413;">β1 </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us"> levels in patients with pancreatic adenocarcinoma (PA). </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Materials and Methods: </span> </b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Thirty-three
patients with a histopathologically confirmed PA diagnosis and sex- and
age-matched 30 healthy controls were included into the current study. Serum </span> <span style="font-size:10pt;color:#131413;">TGF </span> <span style="font-size:10pt;">- <span style="color:#131413;">β1 </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">levels were measured using the ELISA method. </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Median age was
59 (range, 32-84). Of the patients, 61% were male, 70% had good performance
status, and 68% had tumors localized at the head of the pancreas.
Pancreaticoduodenectomy and palliative surgery were performed in 5 (15%) and 4
(12%) of the 9 (27%) patients who underwent surgical procedure. Serum </span> <span style="font-size:10pt;color:#131413;">TGF </span> <span style="font-size:10pt;">- <span style="color:#131413;">β1 </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us"> levels were found to be significantly higher in
patients compared with the control group (p<0.001). A significant
correlation between serum </span> <span style="font-size:10pt;color:#131413;">TGF </span> <span style="font-size:10pt;">- <span style="color:#131413;">β1 </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us"> levels and
clinico-pathological parameters including age, gender, performance status,
tumor locatization, tumor size, metastasis, chemotherapy response, and
laboratory parameters was not detected (p>0.05). </span> <span style="font-size:10pt;">High </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;"> <span style="font-size:10pt;">TGF-β1 levels seems to predict better survival
(p=0.09) </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">
although it was not found significant. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Conclusions: </span> </b> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">Serum </span> <span style="font-size:10pt;color:#131413;">TGF </span> <span style="font-size:10pt;">- <span style="color:#131413;">β1 </span> </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us">
level is a diagnostic biomarker for patients with PA. However, it has neither
predictive nor prognostic value in this group of patients. </span> <span lang="en-us" style="font-size:10pt;" xml:lang="en-us"> </span> </p> <p> </p> <p> </p> <p class="MsoNormal"> <br /> </p>}, number={1}, publisher={Istanbul University}