TY - JOUR TT - Neurobrucellosis AU - Tanyel, ESRA PY - 2017 DA - March DO - 10.21601/ortadogutipdergisi.285452 JF - Ortadoğu Tıp Dergisi JO - omj PB - MEDİTAGEM Ltd. Şti. WT - DergiPark SN - 2548-0251 SP - 39 EP - 41 VL - 9 IS - 1 KW - Nörobruselloz KW - klinik tablolar KW - tedavi N2 - Brucellosisis an endemic zoonotic disease in our country and it is frequently transmittedto humans by ingestion of unpasteurised milk or milk products. Neurobrucellosisis a serious complication of brucellosis and may develop at any stage ofdisease. The clinical spectrum of neurobrucellosis classified as central andperipheral. The most frequent clinical presentations are meningitis, meningoencephalitis,myelitis and cranial nerve paralyses. The psychiatric manifestations(depression, amnesia, psychosis and agitation) were reported inneurobrucellosis cases. Examination of the cerebrospinal fluid an elevatedprotein concentration, a depressed glucose concentration and a moderateleukocytosis compodes mainly of lymphocytes. The isolation rate of Brucella species from cerebrospinalfluid is so low, most of the neurobrucellosis cases were diagnosed byserological methods. Doxycyclie, rifampin, ciprofloxacin, ceftriaxone andtrimethoprim-sulfamethoxazole preferredin the treatment of neurobrucellosis. Effective treatment reduce the sequelaecaused by nervous system damage. CR - 1. Buzgan T, Karahocagil MK, Irmak H et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 2010;14: 469-78. CR - 2. Oueslati I, Berriche A, Ammari L et al. Epidemiological and clinical characteristics of neurobrucellosis case patients in Tunisia. Med Mal Infect 2016;46:123-30. CR - 3. Karsen H, Tekin Koruk S, Duygu F, Yapıcı K, Kati M. 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