@article{article_286607, title={The relationship between acute exacerbation of chronic obstructive pulmonary disease and neutrophile-to-lymphocyte ratio, serum uric acid and gamma-glutamyl transferase levels}, journal={Turkish Journal of Clinics and Laboratory}, volume={8}, pages={105–112}, year={2017}, DOI={10.18663/tjcl.286607}, url={https://izlik.org/JA75KW88XB}, author={Ogan, Nalan and Bağlan Uzunget, Sezen and Ekici, Berkay}, keywords={inflammation,C- reactive protein,Chronic obstructive pulmonary disease,neutrophil/lymphocyte ratio,serum uric acid}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span style="font-family:Arial, sans-serif;font-size:14px;">Aim: </span> </b> <span style="font-family:Arial, sans-serif;"> <span style="font-size:14px;">Chronic inflammation
plays a pathogenic role in chronic obstructive </span> <span style="font-size:14px;">  </span> <span style="font-size:14px;">pulmonary disease. Increase in the ratio of circulating neutrophil to
lymphocyte ratio (NLR), serum uric acid and gamma-glutamyl transferase (GGT) levels </span> <span style="font-size:14px;">  </span> <span style="font-size:14px;">may serve as a marker of systemic
inflammation. The aim of this study is to evaluate the potential predictive
value of blood neutrophil-to- lymphocyte NLR and possible role of serum uric
acid and gamma-glutamyl transferase levels as biomarkers in chronic obstructive
pulmonary disease patients. </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span style="font-family:Arial, sans-serif;font-size:14px;">Material and Methods: </span> </b> <span style="font-family:Arial, sans-serif;font-size:14px;">  </span> <span style="font-family:Arial, sans-serif;"> <span style="font-size:14px;">The sample was derived from a population
of 276 patients admitted for acute exacerbation of chronic obstructive
pulmonary disease to our respiratory medicine department. </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span style="font-family:Arial, sans-serif;font-size:14px;">Results: </span> </b> <span style="font-family:Arial, sans-serif;"> <span style="font-size:14px;"> Higher N/L ratios,
uric acid and GGT levels were detected in chronic obstructive pulmonary disease
patients than in the controls (P < 0.001). Positive correlations between
smoking (pack-years) and NLR, serum GGT, uric acid, and C- reactive protein
levels were found (P < 0.001; r = 0.339, P < 0.001; r = 0.224, P < 0.001;r
= 0.242,and P < 0.001; r = 0.563, respectively). </span> </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span style="font-size:14px;"> </span> <span style="font-size:14px;"> </span> <span style="font-size:14px;"> </span> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span style="font-family:Arial, sans-serif;font-size:14px;">Conclusion: </span> </b> <span style="font-family:Arial, sans-serif;"> <span style="font-size:14px;"> Our study demonstrated
that NLR, serum GGT and uric acid levels are significantly higher in patients
with chronic obstructive </span> <span style="font-size:14px;">  </span> <span style="font-size:14px;">pulmonary
disease. With regard to the associations between chronic obstructive pulmonary
disease and these parameters, they can be used to determine disease burden
besides other risk factors in routine clinical practice. </span> </span> </p> <p> </p> <p> <b> </b> </p> <b> </b>}, number={3}