@article{article_287291, title={SYNTHESIS OF NOVEL FLUOROQUINOLONE-TRIAZOLE HYBRID COMPOUNDS AS ANTIMICROBIAL AGENTS}, journal={Journal of the Turkish Chemical Society Section A: Chemistry}, volume={3}, pages={515–534}, year={2017}, DOI={10.18596/jotcsa.55734}, author={Başoğlu Özdemir, Serap}, abstract={<p> <strong>Abstract: </strong>The hydrazide compound ( <strong>2 </strong>) was synthesized starting from 1-(2-fluorophenyl)piperazine via two stage. The reaction of compound ( <strong>2 </strong>) with different alkyl(aryl)isothiocyanates afforded the corresponding compounds ( <strong>3a-c </strong>) <em>. <strong> </strong> </em>1,3-Thiazolidine derivatives ( <strong>4a-c </strong>) were synthesized from the treatment of ( <strong>3a-c </strong>) <strong> </strong>with ethyl bromoacetate. Mannich bases ( <strong>6a-d </strong>) were yielded the treayment of ( <strong>5a-c) </strong>with various suitable amines in the exictence of formaldehyde. Compound ( <strong>3 </strong>) derivatives were converted to 1,2,4-triazole as the starting material of fluoroquinolone analogues ( <strong>11a-c </strong>). Finally synthesized compounds were examined their biological properties and some of these showed potent activity. </p>}, number={3}, publisher={Turkish Chemical Society}