@article{article_287309, title={SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NEW 1,2,4- TRIAZOLES, MANNICH BASES, CONAZOLES, AND FLUOROQUINOLONES}, journal={Journal of the Turkish Chemical Society Section A: Chemistry}, volume={3}, pages={747–764}, year={2017}, DOI={10.18596/jotcsa.83452}, author={Ceylan, Şule}, keywords={1,2,4-triazole, piperazine, conazole, mannich base, biological activity}, abstract={<p>Triazoles are heterocyclic compounds which have been of interest in the development of novel compounds with antidepressant, anti-inflammatory, analgesic, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, and other activities. In this article, a series of fluorine- and piperazine-containing some novel biologically active 1,2,4-triazole-3-one derivatives were synthesized by the Mannich reaction of triazole intermediates. The structures for novel synthesized compounds were elucidated using elemental analysis and FT IR, <sup>13 </sup>C NMR, <sup>1 </sup>H NMR, EI MS techniques. These compounds were investigated <em>in vitro </em> for their antimicrobial properties and several compounds have fungicidal activity against  <em>Candida albicans </em> and <em>Saccharomyces cerevisiae </em>. And also some of the compounds exhibited excellent activity on <em>Mycobacterium smegmatis </em>, a nonpigmented fast-rising mycobacterium, at the concentration of <1 μg/mL is better than standard drug streptomycin. </p>}, number={3}, publisher={Turkish Chemical Society}