@article{article_288416, title={Evaluation of cases followed and treated due to valproic acid intoxication in child emergency polyclinic between 2010 and 2016}, journal={Konuralp Medical Journal}, volume={9}, pages={7–13}, year={2017}, DOI={10.18521/ktd.288416}, author={Fidancı, İlknur and Güzel, Ahmet}, keywords={Valproic acid,poisoning,child emergency}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Aim: </span> </b> <span lang="en-us" xml:lang="en-us"> The aim
was to determine prognostic factors effecting clinical course of the patients
referring to the Child Emergency Service in our hospital with valproic acid
(VPA) poisoning. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Method: </span> </b> <span lang="en-us" xml:lang="en-us">
Patients who had VPA poisoning diagnoses between 2010 and 2016 in our Child Emergency
Service were retrospectively examined. Demographical characteristics, clinical
findings, laboratory results, treatment methods and effective factors for
prognosis were evaluated for the patients. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Findings: </span> </b> <span lang="en-us" xml:lang="en-us">
114 patients were included in the study. Average age of the patients was
9.91±4.69 years. Sixty-six of the patients were female and forty-eight were
male. The most common reason for inclusion was overdosing (100 patients,
87.72%). Fourteen patients (12.28%) had pure VPA poisoning. VPA serum level
median value was 141.80 µ/mL  (min-max;
102.20 – 640.38 µ/mL). Central nervous system depression was the most common
clinical finding (six patients, 5.2%). Thrombocytopenia was detected in sixteen
patients (14.0%) and hyperammoniemia in eighteen patients (15.8%). Average
follow-up duration for the patients was 16.14 hours. L-carnitine treatment was
applied for six patients (5.3%). </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Result: </span> </b> <span lang="en-us" xml:lang="en-us">In
long-term VPA usage, the importance of thrombocytopenia and ammonia level on
prognosis shouldn’t be forgotten. <b> </b>Supportive
treatment still maintains its importance in VPA intoxication and intensive care
follow-up and treatment was necessary for two patients in our study and L
carnitine was started for patients with suitable indications and preserves its
importance in treatment. </span> </p> <p> </p>}, number={1}, publisher={Duzce University}