TY  - JOUR
TT  - EXAMINATION OF OXIDATIVE STRESS PARAMETERS IN EXPERIMENTAL MESENTERIC ISCHEMIA MODEL
AU  - Tatlı, Özgür
AU  - Karaca, Yunus
AU  - Alver, Ahmet
AU  - Menteşe, Ahmet
AU  - Yuluğ, Esin
AU  - Günaydın, Mücahit
AU  - Şahin, Aynur
AU  - Eryiğit, Umut
AU  - Vahdadi, Samad Shams
AU  - Aygün, Ali
PY  - 2017
DA  - April
DO  - 10.24938/kutfd.292279
JF  - The Journal of Kırıkkale University Faculty of Medicine
JO  - Kırıkkale Uni Med J
PB  - Kirikkale University
WT  - DergiPark
SN  - 2148-9645
SP  - 21
EP  - 29
VL  - 19
IS  - 1
KW  - oxidative stress
KW  - mesenteric ischemia
KW  - experimental
N2  - Amaç:Akut mezenterik iskemi (AMI) tanısında plazma protein karbonil, total antioksidan statüsü (TAS), total oksidan statusu (TOS), oksidatif stres indeksi (OSI) ve malondialdehit (MDA) tanı değerini saptamak.Yöntem:Bu randomize kontrollü deneysel çalışmada, 30 olgun dişi Sprague-Dawley sıçan altı gruba ayrıldı. Grup 1, 3 ve 5, sadece laparotomi yapılan kontrol gruplarıydı. Grup 2, 4 ve 6 laparotomi ve üst mezenterik arter ligasyonu yapılan mezenterik iskemi grupları idi. Cerrahi işlem sonrası 30 dakika (grup 1 ve 2), 2 saat (grup 3 ve 4) ve 6 saat (grup 5 ve 6) kan ve doku örnekleri alındı.Sonuçlar:İskemi ve kontrol grupları arasındaki fark histopatolojik düzeyde istatistiksel olarak anlamlıydı (p = 0.007). İskemi grupları üzerinde histopatolojik hasar görüldü. Histopatolojik hasar, kontrol grubuna kıyasla (2 saat ve 6 saatte) iskemi gruplarında anlamlı olarak daha yüksekti (p = 0.002 ve p = 0.006).Oksidatif stres parametreleri plazma protein karbonil, MDA, TAS, TOS veya OSI'de değerlendirildi.Kontrol ve iskemi gruplarında istatistiksel olarak anlamlı farklılık gözlenmedi.Sonuç:MDA, TAS, TOS ve OSI düzeyleri gruplar arasında istatistiksel olarak anlamlı farklılık gözlenmezken, plazma protein karbonil ve mezenterik iskemi model İskemi ve kontrol grupları gibi oksidatif stresin diğer belirteçleri arasında anlamlı farklılık gösterilmedi.
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UR  - https://doi.org/10.24938/kutfd.292279
L1  - https://dergipark.org.tr/en/download/article-file/296393
ER  -