TY - JOUR TT - Göğüs ağrısı olan hastalarda gebelikle ilişkili Plazma Protein A (PAPP-A) ve iskemi modifiye albümin değerinin karşılaştırılması AU - Tatlı, Özgür AU - Karaca, Yunus AU - Durmuş, İsmet AU - Şahin, Sinan AU - Menteşe, Ahmet AU - Türkmen, Suha AU - Gündüz, Abdulkadir AU - Türedi, Süleyman PY - 2017 DA - October DO - 10.18663/tjcl.292392 JF - Turkish Journal of Clinics and Laboratory JO - TJCL PB - DNT Ortadoğu Yayıncılık A.Ş. WT - DergiPark SN - 2149-8296 SP - 113 EP - 123 VL - 8 IS - 3 KW - PAPP-A KW - IMA KW - chest pain KW - acute coronary syndrome N2 - Amaç: AKS’un erken tanısında PAPP-A ve CK-MB’nin tanısal değerininbelirlenmesidir.Gereçve Yöntemler: Tek merkezli, prospektif, klinik bir çalışma 152 vakaincelendi. Çalışmanın sonunda troponin-T, CK-MB, PAPP-A ve IMA’nın farklıgruplardaki düzeyleri kıyaslandı.Bulgular: 13 hastada STEMI tanısı kondu, 53 hastada NSTEMI/UAP ve 80hastada non spesifik EKG bulguları mevcuttu. Kesin tanısına göre 8 hastadaSTEMI, 36 hastada NSTEMI, 23 hastada UAP ( unstabil njina pektoris), 17 hastadaSAP (stabil anjina pektoris) 68 hastada non koroner göğüs ağrısı mevcuttu.Göğüs ağrısının ilk saatlerinde (0-2 saat, 2-4 saat) en yüksek sensitivitedekien spesifik parametre IMA idi. (Sensitivite/spesifite; 100/30.7, 93.7/52.3).Sonuçlar:Sonuçlarımızagöre, PAPP-A ve IMA, AKS'de troponin-T ve CK-MB gibi bir tanı aracı olarakkullanılamaz. Sonuçlarımız, duyarlılık ve özgüllük özellikleriyle ilgili olarakIMA, göğüs ağrısı erken döneminde AKS tanısında ideal bir tarama testi olarakkullanılamaz. Yine de, IMA, ilk saatler boyunca AKS'yi saptamada bir taramatesti olarak troponin-T, CK-MB ve PAPP-A'ya kıyasla daha yararlı diagnostik biyokimyasalbelirteçtir. Çalışma sonuçlarımız literatürde benzer bir çok araştırmanınaksine bir sonuç sergilemektedir ve bulguları daha kapsamlı bir dizi çalışmaile değerlendirilmelidir. CR - 1. Solinas L, Raucci R, Terrazzino S, et al. 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