TY  - JOUR
TT  - Practıcal Aspects of 68Ga-Labelled Dota-Peptides for Peptide-Receptor Radionuclide Therapy
AU  - Taşdelen, Betül
PY  - 2016
DA  - December
DO  - 10.30931/jetas.297622
JF  - Journal of Engineering Technology and Applied Sciences
JO  - JETAS
PB  - Muhammet KURULAY
WT  - DergiPark
SN  - 2548-0391
SP  - 149
EP  - 155
VL  - 1
IS  - 3
KW  - 68Ga
KW  - DOTANOC
KW  - DOTATATE
KW  - peptides
KW  - PET
N2  - 68Gallium-labeled receptor ligands, such as 68Gallium DOTATOC, 68Gallium-DOTANOC, and68Gallium-DOTATATE which are used in PET are becoming gold standard of 68Ga-labeled peptides.The 68Ga-labeled peptides show a rapid renal clearance and are rapidly accumulated in the tumors (80%within 30 minutes); concentration in tissues without expression of somatostatin receptors is low,providing higher contrast imaging. Here, this paper presents the practical aspects and the results ofpreparation and radiolabelling DOTA-peptides with TiO2-based commercially available 68Ge/68Gagenerator by using fully automated radiopharmaceutical synthesis device. The radiochemical purity(RCP) of 68Ga-labeled DOTA-peptides has been investigated using high performance liquidchromatography (HPLC) and instant thin layer chromatography (ITLC). The labeling procedure resultedin high radiochemical yield. The system allows the fully automated, efficient and rapid preparation of68Ga-DOTA-derivatized peptides.
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UR  - https://doi.org/10.30931/jetas.297622
L1  - https://dergipark.org.tr/en/download/article-file/333837
ER  -