TY  - JOUR
TT  - CYTOGENETIC EFFECTS OF SILICON DIOXIDE ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO
AU  - Tüylü, Berrin Ayaz
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 32
EP  - 32
VL  - Volume 2
IS  - İssue 1 (1)
KW  - CYTOGENETIC EFFECTS OF SILICON DIOXIDE ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO
N2  - Silicon dioxide as a termed Silica ischemically colorless to white and insoluble in water. Silica has widespreadindustrial applications including use as a food additive, anti-foaming agent,and excipient in drugs and vitamins. Crystalline silica is an importantindustrial material that occurs in several forms are used a wide variety ofindustrial settings, including construction, mining, manufacturing, maritime,and agriculture. Occupational exposure tocrystalline silica can lead to the development of disabling and sometimes fatallung diseases, including silicosis and lung cancer.In this studyclastogenic effects of Silica (SiO2) were investigated after 24 and48 hours treatment with cultured human lymphocytes at doses of 1000, 500, 250ve 125 µg/ml by using Cytokinesis Block Micronucleus (CBMN), Sister ChromatidExchange (SCE) and Chromosome Aberration (CA) methods. The results indicate that Silicacaused a cytotoxic andcytostatic effect in human lymphocytes at a concentration 1000, 500 ve250 µg/ml due to decreasedReplicaton Index (RI) and Cell Proliferation Index (CPI). Together withthese findings, statistical increase in the percentage the cells with micronucleus formations (MN),chromosome aberrations (CA) and frequency of Sister Chromatid Exchanges (SCE) were observed at the lowestconcentration (125µg/ml) of Silica.  In conclusion,it can be assumed that the higher concentrations of Silica have significantcytotoxic activity while it has shown considerable cytogenetic in other wordsclastogenic effects only at lowest dose for human peripheral lymphocytes in vitro.
CR  - Anadolu University, Faculty of Science, Department of Biology
UR  - https://dergipark.org.tr/en/pub/turjoem/issue//303819
L1  - https://dergipark.org.tr/en/download/article-file/290791
ER  -