TY  - JOUR
TT  - Chemical Constituents, Cytotoxic, Antioxidant and Cholinesterases Inhibitory Activities of Silene Compacta (Fischer) Extracts
AU  - Boğa, Mehmet
PY  - 2017
DA  - June
DO  - 10.12991/marupj.306789
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 445
EP  - 454
VL  - 21
IS  - 3
KW  - Silene compacta
KW  - LC-MS/MS
KW  - fatty acid
KW  - essential oil
KW  - anticholinesterase
KW  - antioxidant
KW  - cytotoxicity
N2  - Silene türleri Türkiye’de halk arasında mesane ve safra yollarıinfüzyonunda kullanılmaktadır.Silene türleri Avrupa ve Anadolu’da yiyecek olaraktüketilmektedir. Bu çalışmada Silene compacta Fischer (SC)bitkisinin fenolik, yağ asidi ve uçucu yağ kompozisyonlarıile sitotoksik, antioksidan ve antikolinesteraz aktiviteleri,toplam fenolik ve flavonoid içerikleri çalışılmıştır. Uçucu yağve yağ asidi bileşenleri GC-MS cihazı ile belirlendi. Metanolekstresinin kimyasal bileşimi kalitatif ve kantitatif olarakLC-MS/MS cihazı ile belirlendi. Uçucu yağ ve yağ asidinin anabileşenleri sırasıyla α-selinen (%12.4) ve palmitik asit (%26.3)olarak belirlendi. Çalışılan dört antioksidan test yöntemlerindeaktif olan methanol ekstresi çok güçlü antikolinesteraz enziminhibisyon aktivitesi göstermiştir. Aynı zamanda methanolekstresinin A549 hücre serilerine karşı en yüksek sitotoksiketkiyi gösterdiği belirlenmiştir. Metanol ekstresinin LC-MS/MSanalizi sonucuna göre ana bileşenleri hesperidin, rutin, kuinikasit ve malik asit olarak belirlenmiştir.
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UR  - https://doi.org/10.12991/marupj.306789
L1  - https://dergipark.org.tr/en/download/article-file/294735
ER  -