TY - JOUR TT - Antioxidant Activity and Fatty Acid Composition of Seseli tortuosum AU - Uysal, Sengul AU - Zengin, Gokhan AU - Guler, Gokalp Ozmen AU - Aktumsek, Abdurrahman PY - 2017 DA - October JF - Selcuk University Journal of Science Faculty JO - sufefd PB - Selcuk University WT - DergiPark SN - 2458-9411 SP - 175 EP - 188 VL - 43 IS - 2 KW - Antioksidan aktivite KW - yağ asidi bileşimi KW - fenolik içerik KW - Seseli tortuosum N2 - Manystudies have shown the benefits deriving from plants secondary metabolites tohuman health also for the prevention of several diseases associated tooxidative stress. In this work, the antioxidant activity of Seseli tortuosum was investigated bydifferent chemical methods including free radical scavenging (DPPH assay),reducing power (FRAP and CUPRAC assays), total antioxidant capacity(β-caroten/linoleic acid and phosphomolybdate assays). Also, total phenoliccontent were detected by Folin-Ciocalteu assay. BHA, BHT and Trolox were usedas standards in these antioxidant assays. The fatty acid composition of S. tortuosum was also evaluated by gaschromatography (GC). Total phenolic content in the extract was detected as36.58 mgGAE/g extract. The extract possesses antioxidant activity in aconcentration-dependent manner at the antioxidant assays. Twenty-four fattyacids were identified in the S. tortuosumoil. Among fatty acids, the main component was linoleic acid (C 18:2 ω6)(34.57%). The content in unsaturated fatty acids (UFAs) was higher than that ofsaturated fatty acids (SFAs). From these results, S. tortuosum could be considered as a valuable source for designingnovel food and pharmaceutical products. CR - 1. Halliwell B, J.M.C. G. Free radicals in Biology and Medicine, 3 rd ed. Oxford University Press. 1999;New York, USA:10-121. 2. Aruoma OI. Assessment of potential prooxidant and antioxidant actions. Journal of the American Oil Chemists' Society. 1996;73(12):1617-25. 3. Hou W-C, Lin R-D, Cheng K-T, Hung Y-T, Cho C-H, Chen C-H, et al. Free radical-scavenging activity of Taiwanese native plants. Phytomedicine. 2003;10(2-3):170-5. 4. Fridovich I. Superoxide radical and superoxide dismutases. Annual review of biochemistry. 1995;64(1):97-112. 5. Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? The lancet. 1994;344(8924):721-4. 6. Barlow S, Schlatter J. Risk assessment of carcinogens in food. Toxicology and applied pharmacology. 2010;243(2):180-90. 7. Vinson JA, Dabbagh YA, Serry MM, Jang J. Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease. Journal of Agricultural and Food Chemistry. 1995;43(11):2800-2. 8. Gonçalves MJ, Tavares AC, Cavaleiro C, Cruz MT, Lopes MC, Canhoto J, et al. Composition, antifungal activity and cytotoxicity of the essential oils of Seseli tortuosum L. and Seseli montanum subsp. peixotoanum (Samp.) M. Laínz from Portugal. Industrial Crops and Products. 2012;39:204-9. 9. Ilić MD, Jovanović VPS, Mitić VD, Jovanović OP, Mihajilov-Krstev TM, Marković MS, et al. Comparison of chemical composition and biological activities of Seseli rigidum fruit essential oils from Serbia. Open Chemistry. 2015;13(1). 10. Küpeli E, Tosun A, Yesilada E. Anti-inflammatory and antinociceptive activities of Seseli L. species (Apiaceae) growing in Turkey. Journal of ethnopharmacology. 2006;104(3):310-4. 11. Baytop T. Therapy with Plants in Turkey (Past and Present). 2nd ed Nobel Medical Book House, Istanbul. 1999. 12. Baytop T. Türkçe Bitki Adları Sözlügü, Atatürk Kültür, Dil ve Tarih Yüksek Kurumu, TDKY 3578. TTK Basimevi, Ankara. 1994. 13. Slinkard K, Singleton VL. Total phenol analysis: automation and comparison with manual methods. American Journal of Enology and Viticulture. 1977;28(1):49-55. 14. Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Analytical biochemistry. 1999;269(2):337-41. 15. Dapkevicius A, Venskutonis R, van Beek TA, Linssen JP. Antioxidant activity of extracts obtained by different isolation procedures from some aromatic herbs grown in Lithuania. Journal of the Science of Food and Agriculture. 1998;77(1):140-6. 16. Sokmen A, Gulluce M, Akpulat HA, Daferera D, Tepe B, Polissiou M, et al. The in vitro antimicrobial and antioxidant activities of the essential oils and methanol extracts of endemic Thymus spathulifolius. Food control. 2004;15(8):627-34. 17. Sarikurkcu C. Antioxidant activities of solvent extracts from endemic Cyclamen mirabile Hildebr. tubers and leaves. African Journal of Biotechnology. 2011;10(5):831-9. 18. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical biochemistry. 1996;239(1):70-6. 19. Apak R, Güçlü K, Özyürek M, Esin Karademir S, Erçağ E. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. International Journal of Food Sciences and Nutrition. 2006;57(5-6):292-304. 20. IUPAC. Standards methods for Analysis of oils, fats and derivatives Paquot, C. (ed.),. 6th edn, Oxford: Pergamon Press, . 1979:59-66. 21. Matejić J, Džamić A, Mihajilov-Krstev T, Ranđelović V, Krivošej Z, Marin P. Total phenolic content, flavonoid concentration, antioxidant and antimicrobial activity of methanol extracts from three Seseli L. taxa. Open Life Sciences. 2012;7(6):1116-22. 22. Jakovljević D, Vasić S, Stanković M, Čomić L, Topuzović M. In vitro biological activity of secondary metabolites from Seseli rigidum Waldst. et Kit.(Apiaceae). Acta biologica hungarica. 2015;66(4):395-405. 23. Abas F, Khatib A, Shaari K, Lajis NH. Chemical characterization and antioxidant activity of three medicinal Apiaceae species. Industrial Crops and Products. 2014;55:238-47. 24. Coruh N, Celep AS, Özgökçe F. Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food chemistry. 2007;100(3):1237-42. 25. Pandey MM, Vijayakumar M, Rastogi S, Rawat AK. Phenolic content and antioxidant properties of selected Indian spices of Apiaceae. Journal of herbs, spices & medicinal plants. 2012;18(3):246-56. 26. Zengin G, Ceylan R, Uysal S, Aktumsek A. Biological Activities of Three Extracts from Artedia squamata: A Study on Antioxidant and Enzyme Inhibitory Potential. Current Bioactive Compounds. 2015;11(3):152-5. 27. Zengin G, Bulut G, Mollica A, Haznedaroglu MZ, Dogan A, Aktumsek A. Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches. Food and Chemical Toxicology. 2017. 28. Caprioli G, Fiorini D, Maggi F, Marangoni M, Papa F, Vittori S, et al. Ascorbic acid content, fatty acid composition and nutritional value of the neglected vegetable Alexanders (Smyrnium olusatrum L., Apiaceae). Journal of Food Composition and Analysis. 2014;35(1):30-6. 29. Saracoglu HT, Zengin G, Akin M, Aktumsek A. Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. Natural product research. 2012;26(13):1188-94. 30. Saraçoğlu HT, Zengin G, Akin M, Aktümsek A. A comparative study on the fatty acid composition of the oils from five Bupleurum species collected from Turkey. Turkish Journal of Biology. 2012;36(5):527-32. UR - https://dergipark.org.tr/en/pub/sufefd/issue//310567 L1 - https://dergipark.org.tr/en/download/article-file/357279 ER -