TY  - JOUR
TT  - THE CYTOTOXIC EFFECT AND THE PHYSIOLOGICAL RESPONSE IN THE BIOMATERIALS APPLICATIONS
AU  - Emın, Nuray
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 226
EP  - 226
VL  - Volume 2
IS  - İssue 1 (1)
KW  - THE CYTOTOXIC EFFECT AND THE PHYSIOLOGICAL RESPONSE IN THE BIOMATERIALS APPLICATIONS
N2  - The materialsused to provide structures and/or functions in a living system are calledbiomaterials. They are commonly synthetic materials used to treat an injury orto function in intimate contact with living organism. Biologically, chemicallyand mechanically acceptance of a medical implant by the whole body is veryimportant. And this is a prerequisite for material’s biocompatibility.Biocompatibility is the appropriate host response against the material'sability in a specific application. This physiological response includesdeficiency of blood clotting, resistance of bacterial colonization and normal bodyheating.  The biomaterials and theirdegradation products must be biocompatible with host tissues: i.e. non-toxic,non-allergic, non-carcinogenic, and non-inflammatory. The cytotoxic effect of amaterial causes cell death, resulting in tissue degradation. Thus, toxicitymust be determined prior the transplantation. Toxicity of biomaterials isdetermined by some testings based on in vitro cell culture. ISO 10993-5regulated these methods with three testing categories. These testing categoriesare based on direct cell-material contact, indirect cell-material interactionsand location of applications within the host. The selected cell type (e.g.somatic cell types, mesenchymal stem cells, cell lines etc.) and the origin ofcells (human or other mammalians, tissue type etc.) are very important forcytotoxic testing. On the other hand qualitative or quantitative methodchoosing is also important parameter for cytotoxic testing. Consequently, allof these toxicity tests generally consists in determining the number of cellsin proliferative stage.  
CR  - Nuray EMIN
CR  - Kastamonu University, Faculty of Engineering and Architecture, Biomedical Engineering Division, Kastamonu, Turkey
UR  - https://dergipark.org.tr/en/pub/turjoem/issue//310945
L1  - https://dergipark.org.tr/en/download/article-file/300334
ER  -