TY  - JOUR
TT  - HISTOPATHOLOGICAL EFFECTS OF THIOUREA DIOXIDE ON INTESTINE TISSUE OF ZEBRAFISH (Danio rerio
AU  - Akbulut, Cansu
AU  - Fidan, Büşra
AU  - Zengin, Mustafa
AU  - Yön, Nazan Deniz
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 255
EP  - 255
VL  - Volume 2
IS  - İssue 1 (1)
KW  - HISTOPATHOLOGICAL EFFECTS OF THIOUREA DIOXIDE ON INTESTINE TISSUE OF ZEBRAFISH (Danio rerio
N2  - Investigationthe histopathological effects of thiourea dioxide on intestine tissue ofzebrafish were aimed.Thioureadioxideis an organosulfur compound which is a strong reducing agent. It is generallyused as decolorisation agent, bleach in textile industry. In the otherindustrial fields such as leather processing, photographic, paper, pulp andboard industry it has a wide range of use. Industrial waste products have beencontaminated aquatic environment day after day. After one-weekadaptation period zebrafish divided into three group (n=10) as one control and2 experimental groups (3mM, 4.5mM). For investigating the effects of thioureadioxide, intestine tissues were dissected after 5 day of the exposure. Tissueswere fixed with 10% neutral buffered formalin and dehydration were carried outin an ascending series of ethanol. Tissues were cleared in xylene, embedded inparaffin wax and cut into 5 µm sections on a microtome. The sections werestained with hematoxylin (H&E). Results were evaluated with lightmicroscope.In control groupnormal intestine histology have been observed. In 3 mM thiourea dioxide exposedgroup, hypertrophy and edema at muscularis externa, degeneration and necrosisat villi structure, deterioration and vacuolization at lamina propria andincrease in the number of goblet cells were observed. In 4.5 mM thioureadioxide exposed group, severe edema and hemorrhage in muscularis externa,degeneration at villi structure and vacuolization at mucosa layer weremonitored.
CR  - Cansu AKBULUT, Büşra FİDAN, Mustafa ZENGİN, Nazan Deniz YÖN
CR  - Sakarya University Science and Letters Faculty Department of Biology, Sakarya, Turkey
Sakarya University Science and Letters Faculty Department of Chemistry, Sakarya, Turkey
UR  - https://dergipark.org.tr/en/pub/turjoem/issue//311547
L1  - https://dergipark.org.tr/en/download/article-file/301183
ER  -