TY  - JOUR
T1  - Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations
AU  - Saeidian, Hamid
PY  - 2017
DA  - December
JF  - Turkish Computational and Theoretical Chemistry
JO  - Turkish Comp Theo Chem (TC&TC)
PB  - Koray SAYIN
WT  - DergiPark
SN  - 2587-1722
SP  - 1
EP  - 5
VL  - 1
IS  - 2
LA  - en
AB  - Theproton and sodium ion affinities of Topiramate has been investigated by DFTapproach. The most basic site for protonation on Topiramate is nitrogen atom ofsulfamate group. It is also interestingthat sodium ion affinity of Topiramate was determined as 670 kJ mol-1is less than its proton ion affinity. Because of the limited understanding of the biologicalmolecular mechanism of Topiramate, these results might devise a clearunderstanding of the role of Topiramate in blockade of voltage-dependent sodiumchannels in biological systems.
KW  - Topiramate
KW  - anticonvulsant drug
KW  - DFT calculation
KW  - sodium ion affinity
KW  - Theoretical chemistry
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UR  - https://dergipark.org.tr/en/pub/tcandtc/issue//312262
L1  - https://dergipark.org.tr/en/download/article-file/381619
ER  -