TY  - JOUR
TT  - Swiss albino farelerde-Mus musculus, tartrazin’in neden olduğu fizyolojik ve biyokimyasal parametrelerindeki değişiklikler
AU  - Arefin, Sayema
AU  - Hossain, Mohammad Salim
AU  - Neshe, Shamme Akter
AU  - Rashid, Md. Mamun Or
AU  - Tohidul Amin, Mohammad
AU  - Hussain, Md. Saddam
PY  - 2017
DA  - June
DO  - 10.12991/marupj.319304
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 564
EP  - 569
VL  - 21
IS  - 3
KW  - Azo-Dye
KW  - tartrazine
KW  - Swiss Albino Mice
KW  - Physiological changes
KW  - Serum biochemistry
N2  - Günümüzde sentetik gıda boyaları, şekerlemelerde, ilaçlarda vekozmetiklerde renklendirici olarak sıklıkla kullanılmaktadır.Çalışmamızda, geniş kullanım alanı olan bir azo boyar maddetartrazin’inSwiss albino farelerdeki toksik etkilerinin tespitedilmesi hedeflendi. Normal diyetle beslenen laboratuvarhayvanlarına tartrazin 200mg/kg ve 400mg/kg dozlardauygulandı. Tartrazin’in toksik etkisini incelemek için çeşitlifizyolojik ve biyokimyasal parametreler değerlendirildi.Çalışmamızda tartrazin’in 400 mg / kg dozunda uygulandığıgrupta yer alan farelerde kontrol grubuna kıyasla vücut ağırlığıartışında belirgin bir düşüş olduğu tespit edildi.Kalp, böbrek ve karaciğer gibi hayatî organların ortalamaağırlığında önemli farklılıklar gözlendi. Kalbin ve böbreklerinortalama ağırlıkları artarken, karaciğerin ortalama ağırlığıönemli derecede azaldığı tespit edildi. Tartrazin’in uygulandığıgrupta yer alan farelerde serum trigliserid, kreatinin ve bilirubindüzeyleri anlamlı olarak artarken kolesterol düzeyinin azaldığıtespit edildi.
CR  - 1. Saxena B, Sharma S. Serological changes induced by blend of
sunset yellow, Metanil yellow and tartrazine in swiss albino
rat, Rattus norvegicus. Toxicol Int 2014;21:65-8.
2. Himri I, Bellahcen S, Souna F, Belmekki F, Aziz M, Bnouham
M, Zoheir J, Berkia Z, Mekhfi H, Saalaoui E. A 90-day oral
toxicity study of Tartrazine, a synthetic food dye, in Wistar
rats. Int J Pharm Pharm Sci 2011;3: 159-69.
3. Devlin J, David TJ. Tartrazine in atopic eczema. Arch Dis
Child 1992; 67: 709-11.
4. Inomata N, Osuna H, Fujita H, Ogawa T, Ikezawa Z. Multiple
chemical sensitivities following intolerance to azo dye in
sweets in a 5-year-old girl. Allergol Int 2006;55:203-5.
5. Hannuksela M, Haahtela T. Food additive hypersensitivitynear
myth. Duodecim 2009; 125:527-32.
6. Mpountoukas P, Pantazaki A, Kostareli E, Christodoulou
P, Kareli D, Poliliou S. Cytogenetic evaluation and DNA
interaction studies of the food colorants Amaranth,
Erythrosine and Tartrazine. Food Chem Toxicol 2010;48:
2934-44.
7. Gao Y, Li C, Shen J, Yin H, An X, Jin H. Effect of food azo
dye tartrazine on learning and memory functions in mice
and rats, and the possible mechanisms involved. J Food Sci
2011;76:T125-9.
8. Rowe KS, Rowe KJ. Synthetic food coloring and behavior: A
dose response effect in a double-blind, placebo-controlled,
repeated measures study. J Pediat 1994;125:691-8.
9. Borzelleca, JF, Hallagan JB. Chronic toxicity/carcinogenicity
studies of FD & C yellow nº 5(Tartrazine) in rats. Food Chem
Toxicol 1988;26: 179‐87.
10. Maekawa A, Matsuoka C, Onodera H, Tanigawa H, Furuta K,
Kanno J, Jang JJ, Hayashi Y, Ogiu T. Lack of Carcinogenecity
of Tartrazine (FD & C YELLOW Nº 5) in the F344 Rat. Food
Chem Toxicol 1987;25:891‐6.
11. Neshe SA, Arefin S, Hussain MS., Das A, Karmakar P, Hossain
MS. Safety evaluation of chocolate brown dye in Swiss albino
mice. J Nutr Disorders Ther 2016; 6:195.
12. Joint FAO/WHO Expert Committee on Food Additives:
Specifications for the identity and purity of food additives
and their toxicological evaluation: Food colors and some
antimicrobials and antioxidants (JECFA) 1965.
13. Poul M, Jarry G, Elhkim MO, Poul JM. Lack of genotoxic
effect of food dyes amaranth, sunset yellow and tartrazine and
their metabolites in the gut micronucleus assay in mice. Food
Chem Toxicol 2009;47:443-8.
14. Aboel‐Zahab H, El‐Khyat Z, Sidhom G, Awadallah R, Abdelal
W, Mahdy K. Physiological effects of some food coloring
additives on rats. Boll Chim Farm 1997;136:615-27.
15. Helal GE, Zaahkouk AM, Mekkaway AH. Effect of some food
colorants (Synthetic and Natural Products) of young Albino
rats. Egyptian J Hosp Med 2000;1:103-13.
16. Sharma G, Gautam D, Goyal RP. Tartrazine induced
haematological and serological changes in female Swiss albino
mice, Mus musculus. Pharmacologyonline 2009;3: 774-8.
17. Osman MA, Afifi A, Hussein RM, Kamilia B, Abdel Aziz I,
Salah SH. Long-Term biochemical and genotoxicity studies of
four synthetic food and drug colorants in mice. Bull Faculty
Pharm (Cairo Univ.) 1995;1:13-21.
18. Mehedi N, Mokrane N, Alami O, Tabet SA, Zaoui C, Kheroua
O, Saidi D. A thirteen week ad libitum administration toxicity
study of tartrazine in Swiss mice. Afr J Biotechnol 2013;12:
4519-29.
19. Timbrell JA. Principles of biochemical toxicology, 4th edition.
Informa Healthcare, New York. 2009.
20. Al-Shinnawy MS, Elkattan NA. Assessment of the changes in
some diagnostic parameters in male albino rats fed on an azo
yye. Int J Environ Sci Eng 2013; 4:85-90.
21. Amin KA, Abdel Hameid H, AbdElsttar AH. Effect of
food azo dyes tartrazine and Carmoisine on biochemical
parameters related to renal, hepatic function and oxidative
stress biomarkers in young male rats. Food Chem Toxicol
2010;48:2994-9.
22. Breckenridge WC, Little JA, Alaupovic P, Wang CS, Kuksis A,
Kakis G, Lindgren F, Gardiner G. Lipoprotein abnormalties
associated with a familial deficiency of hepatic lipase.
Atherosclerosis 1982; 45:161-79.
23. Connely PW, Maruire GF, Lee M, Little JA. Plasma lipoproteins
in familial hepatic lipase deficiency. Arteriosclerosis
1990;10:40-8.
24. Dixit S, Purshottam SK, Khanna SK, Das M. Usage pattern
and exposure assessment of food colours in different age
groups of consumers in the state of Uttar Pradesh, India. Food
Addit Contam Part A Chem Anal Control Expo Risk Assess
2010;27:181-9.
UR  - https://doi.org/10.12991/marupj.319304
L1  - https://dergipark.org.tr/en/download/article-file/317104
ER  -