@article{article_319789, title={DNA- Binding, Biological Activities, and Chemical Composition of Wild Growing Epilobium angustifolium L. Extracts from Canakkale, Turkey}, journal={Journal of the Turkish Chemical Society Section A: Chemistry}, volume={4}, pages={811–840}, year={2017}, DOI={10.18596/jotcsa.319789}, author={Sayık, Aysema and Yusufoğlu, Ayşe Sergüzel and Açık, Leyla and Türker, Gülen and Aydın, Betül and Arslan, Leyla}, keywords={DNA-Binding activity, pBR322 plasmid DNA-Binding, , Epilobium angustifolium L. extracts, cancer therapeutic, chemical analysis¬¬¬}, abstract={<font face="Times New Roman" size="3"> </font> <p style="margin:0cm 0cm 10pt;text-align:justify;"> <span style="line-height:115%;font-family:Verdana, sans-serif;font-size:10pt;"> <span style="font-size:12px;">The usage of </span> <b> <span style="font-size:12px;"> </span> </b> <i> <span style="font-size:12px;">Epilobium
angustifolium L. </span> </i> <span style="font-size:12px;"> in folk medicine against prostate and skin diseases encouraged
us to investigate pBR322 DNA-binding ability, biological activities and
chemical composition of wild growing </span> <i> <span style="font-size:12px;">Epilobium
angustifolium L </span> </i> <span style="font-size:12px;">.’s methanolic, ethanolic and aqueous extracts from
Canakkale, Turkey. DNA-binding activity was studied by agarose gel
electrophoresis and chemical composition via GC, GC-MS, HPLC, LC-MS, ICP-MS and
AAS. Literature survey indicates no data on pBR322 plasmid DNA interaction of </span> <i> <span style="font-size:12px;">Epilobium </span> </i> <span style="font-size:12px;"> species which is an important
criteria for being a potential anticancer agent. Antibacterial and antifungal
effects were tested against 11 bacterias and 3 fungis and compared with
ampicillin, chloramphenicol and ketokanozol by agar well diffusion techniques. Total
phenolic content was found by Folin-Ciocalteu method and antioxidant activity
was obtained by DPPH and Fe (II)-FZ (ferric-ferrozine) </span> <span style="font-size:12px;">  </span> <span style="font-size:12px;">methods. This plant is rich of flavonoids, </span> <span style="font-size:12px;">  </span> <span style="font-size:12px;">hormones, </span> <span style="font-size:12px;">  </span> <span style="font-size:12px;">fatty and phenolic acids. Si, K, </span> <span style="font-size:12px;">  </span> <span style="font-size:12px;">Mg, P and Mn were the main inorganic elements. </span> <i> <span style="font-size:12px;">Epilobium angustifolium </span> </i> <span style="font-size:12px;"> L. with its high DNA-binding activity and
rich chemical composition can be a good potential anticancer, antimicrobial and
antioxidant prodrug. </span> <span> <span style="font-size:12px;">  </span> </span> </span> </p> <font face="Times New Roman" size="3"> </font>}, number={3}, publisher={Turkish Chemical Society}