TY  - JOUR
TT  - Molecular mechanism and toxic effects of anti-coagulant rodenticides
AU  - Karayıldırım, Çinel Köksal
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 50
EP  - 50
VL  - Volume 2
IS  - Issue 1(2)
KW  - Molecular mechanism and toxic effects of anti-coagulant rodenticides
N2  - Objective: Rodenticides arepesticides that consumed by target mammals and can lead to secondary exposure of predators. Anticoaugulantrodenticides (LAARs) are widely used for harmful rodent control purposes. LAARs aredivided into two main groups which are the first generation and second generation. Second generationrodenticides show higher toxicity and they are lethal for rodents in a single feeding withlower concentrations due to the affinity to binding sites in the liver and greater accumulation andpersistence. However first generation rodenticides generally require higher concentration and consecutiveintake over days in order to accumulate the lethal dose. The aim of this presentation to reviewedmolecular mecanisms and toxic effects which were reported in literatures for anticoagulantrodenticides. Methods: Anticoagulant rodenticidesinhibit vitamin K epoxide reductase (VKOR) which is an electron carrier vitally involved inthe oxidation reduction cycle leading to γ-carboxylation. Vitamin K is a cofactor of primary importancein the blood coagulation process as it contributes to the activation of blood subsequentlyclotting factors (II, VII, IX, and X). The greater potency and duration of action of long-actinganticoagulant rodenticides is attributed to their affinity for vitamin K, their ability to disrupt thevitamin K epoxide cycle at more than one point, hepatic accumulation and unusually long biologicalhalf-lives due to high lipid solubility and enterohepatic circulation. After exposure to LAAR can thereforelead to a progressive decrease in blood clotting factor between 12 and 24 h after intoxicationresulting in massive bleeding episodes that are potentially fatal. Results: This presentation provide acomprehensive understanding of LAAR molecular mecanism which causes by vitamin K. Conclusion: In summary, the presentedinformation about Molecular mechanism and toxic effects of anti-coagulant rodenticides, isuseful for the researchers especially those who are involved in manufacture processes. Keywords: Rodenticides,Anticoagulant, Toxicity
CR  - Çinel Köksal Karayıldırım
CR  - Ege Üniversitesi, İlaç Geliştirme ve Farmakokinetik Araştırma Uygulama Merkezi
UR  - https://dergipark.org.tr/en/pub/turjoem/issue//321658
L1  - https://dergipark.org.tr/en/download/article-file/314745
ER  -