@article{article_322894, title={Effect of methylphenidate treatment on heart rate variability in children with attention-deficit hyperactivity disorder}, journal={Cukurova Medical Journal}, volume={42}, pages={271–276}, year={2017}, DOI={10.17826/cutf.322894}, url={https://izlik.org/JA62GN67GT}, author={Karpuz, Derya and Hallıoğlu, Olgu and Toros, Fevziye and Taşdelen, Bahar}, keywords={Attention-Deficit Hyperactivity Disorder,Heart Rate Variability,Methylphenidate}, abstract={<p class="z">Purpose: The aim of the present study is to determine the effect of attention deficit and hyperactivity disorder and the use of methylphenidate for its treatment on autonomic function dysfunction by using   heart rate variability. </p> <p class="z">Material and Methods: Parameters of untreated attention deficit and hyperactivity disorder patients (n=99), patients who have been on MPH treatment for last three months methylphenidate group) (n=100) and 125 healthy children similar age and sex were compared. Electrocardiographic data were obtained by recording 200 heart beats in supine position, and records were   collected with PC-based ECG acquisition system (PC-ECG 1200) and evaluated.  </p> <p class="z">Results: Mean standard deviation of NN interval (SDNN) and root mean square of the successive differences (RMSSD) were lower  both in untreated attention deficit and hyperactivity disorder and methylphenidate groups  compared to control groups, but only in methylphenidate group, it was significantly lower. It was also determined that LF values were higher in both untreated attention deficit and hyperactivity disorder and methylphenidate groups and the difference between methylphenidate group and controls were statistically significant.    </p> <p class="z">Conclusion: In children with attention deficit and hyperactivity disorder, parasympathetic activity decreased, indicating autonomic dysfunction and this decrease was more marked in patients on methylphenidate.  Therefore, in patients using methylphenidate, care should be exercised for cardiovascular risks such as arrhythmia and sudden cardiac death. </p> <div> <br /> </div>}, number={2}