@article{article_327084, title={Can Procalcitonin Help The Diagnosis of Osteomyelitis in Adults?: A Prospective Study}, journal={Ahi Evran Medical Journal}, volume={1}, pages={25–29}, year={2017}, author={Karsen, Hasan and Güler, Emine Ayça and Kirmit, Adnan and Yıldırım, Süleyman}, keywords={Procalcitonin,osteomyelitis}, abstract={<p class="MsoNormal" style="margin-left:35.4pt;text-indent:-35.4pt;line-height:150%;"> <b> <span>SUMMARY </span> </b> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span xml:lang="en-us" lang="en-us">Aim: </span> </b> <span xml:lang="en-us" lang="en-us"> The aim of this study was to
evaluate the sensitivity, specificity and predictive values of procalcitonin in
adults patients with osteomyelitis. </span> <span> </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span xml:lang="en-us" lang="en-us">Material and Methods: </span> </b> <span xml:lang="en-us" lang="en-us"> A total of
30 consecutive patients with osteomyelitis and 30 healthy controls were
enrolled in this study. The white blood cell count, erythrocyte sedimentation
rate, C-reactive protein and procalcitonin (PCT) levels of the patients and
controls were detected. Procalcitonin was measured by an Enzyme-Linked
Immunosorbent Assay (Ray Bio <sup>® </sup>Human Procalcitonin ELISA Kit, <b>Norcross
GA, USA). </b>Values of PCT levels >0,5 ng/ml were considered as high than
normal. </span> <span> </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span xml:lang="en-us" lang="en-us">Results: </span> </b> <span xml:lang="en-us" lang="en-us"> Among 30 patients included in
the study 4 of them were subacute osteomyelitis while 26 of them were chronic
osteomyelitis. The ratio of the female to male both in patients and the control
group was 10/20. The mean age of the patients was 31,16 ±15,32 years, while in
control group 32,22±14.32 years. 26 (86,7%) of the patients had clinical signs
and symptoms of osteomyelitis. White blood cell count detected high in 5
(16.6%) of them, erythrocyte sedimentation rate was high in 20 (66.6%) of them
and  C-reactive protein was positive in 15 (50%) patients, but PCT levels
found to be higher in all 30 (100%) patients (PCT>0.5 ng/mL). In our study,
the PCT test, with a 0.5 ng/mL cut-off value, had a sensitivity of 100%, a
specificity of 56% and a positive predictive value of 100%. The PCT test, with
a 0.57 ng/mL cut-off value, had a sensitivity of 87%, a specificity of 86% and
a positive predictive value of 87%.  This cut-off value (0.57 ng/mL) is
quite suitable in osteomyelitis patients. </span> <span> </span> </p> <p class="MsoNormal" style="line-height:150%;"> <b> <span xml:lang="en-us" lang="en-us">Conclusion: </span> </b> <span xml:lang="en-us" lang="en-us">The sensitivity, specificity, and positive
predictive values of PCT test are more discriminative than the other acute
phase reactants in the patients with osteomyelitis. Therefore, the PCT test can
be used as a useful marker in the diagnosis of osteomyelitis. </span> <span> </span> </p> <p class="MsoNormal" style="line-height:150%;">  </p>}, number={2}, publisher={Kirsehir Ahi Evran University}