TY  - JOUR
T1  - GIDALARDA BULUNAN BİYOJEN AMİNLERİN ÖNEMİ VE DETOKSİFİKASYON MEKANİZMALARI
TT  - THE IMPORTANCE OF BIOGENIC AMINES IN THE FOODS FOR HEALTH AND THEIR DETOXIFICATION MECHANISMS
AU  - Akan, Sadiye
AU  - Demirağ, Mustafa Kemal
PY  - 2018
DA  - July
DO  - 10.3153/FH18017
JF  - Food and Health
JO  - Food Health
PB  - Özkan ÖZDEN
WT  - DergiPark
SN  - 2602-2834
SP  - 166
EP  - 175
VL  - 4
IS  - 3
LA  - tr
AB  - Günümüzdegıdalarda iz miktarlarda bulunan fakat sağlık açısından önemli etkiler gösterenbileşiklerin belirlenmesi üzerine yapılan çalışmalar devam etmektedir. Biyojenaminler de özellikle proteince zengin gıdalarda ve fermente gıdalardamikrobiyal dekarboksilasyon veya aldehitlerin ve ketonların deaminasyonu sonucuoluşan ve sağlık açısından birçok etkileri olan bileşikler olarak buaraştırmalara konu olmaktadır. Biyojen aminler vücutta birçok fizyolojikfonksiyonun düzenlenmesinde görev almakla birlikte vücutta yüksekkonsantrasyonlarda bulunduklarında ise toksik etki gösterebilmektedirler.Biyojen aminler vücut sisteminde amino oksidaz enzimleri tarafından detoksifiye(katabolize) edilebilmekte olup, bazı durumlarda bu enzimlerin yeterinceaktivite gösterememesi sonucu bu aminler vücutta toksik etkigösterebilmektedirler. Bu derlemede, biyojen aminlerin fizyolojik etkileri,toksik etkileri ve detoksifikasyon mekanizmaları güncel literatürlerincelenerek tartışılmıştır.
KW  - Biyojen aminler
KW  - Fizyolojik etki
KW  - Toksik etki
KW  - Detoksifikasyon
N2  - Nowadays,the researches about determination of compounds that are present at traceamounts in foods and have significant effects on health have been proceeded.Biogenic amines, which are formed by microbial decarboxylation or deaminationof aldehites and ketones, especially in the foods rich in proteins andfermented foods and have many effects on human health, subject to the so-calledresearches. Biogenic amines play important roles in the regulation of manyphysiological functions in the body, however excessive intake of biogenicamines could lead to toxicological effects. These amines are detoxified(catabolized) by amine oxidase enzymes in the body, however biogenic amines maycause toxicological effects in cases enzymes at issue are inactivated by somesubstances. In this review, the physiological and toxicological effects ofbiogenic amines and their detoxification mechanisms are discussed.
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UR  - https://doi.org/10.3153/FH18017
L1  - https://dergipark.org.tr/en/download/article-file/440002
ER  -