@article{article_330704, title={Oral kavite ve orofarengeal skuamöz hücreli kanserlerinde p16 pozitifliğinin etkisi}, journal={ENT Updates}, volume={7}, pages={17–21}, year={2017}, author={Aslan, Hale and Özkul, Yılmaz and Pınar, Ercan and Işık, Elif and Aladağ, İbrahim and İmre, Abdülkadir and Songu, Murat and Etit, Demet}, keywords={oral kavite kanseri,kanser,p16 pozitifliği,p16 positivity,oral cavity cancer,oropharyngeal cancer}, abstract={<p> <b>Objective: </b> To determine the frequency of p16 positivity in oral cavity and oropharyngeal squamous cell carcinoma (OC/OP-SCC) and to reveal whether there is a difference between p16-positive and -negative cases according to clinicopathological parameters. <br> <b>Methods: </b> p16 antibody was retrospectively analyzed immunohistochemically in biopsies of 60 patients with OC/OP-SCC operated between 2007 to 2015. Comparison was performed for age, sex, smoking habit, alcohol consumption, site of the tumor, the level of keratinization, T stage, lymphovascular invasion, perineural invasion, recurrence of the tumor, and survival. <br> <b>Results: </b> Of the 60 patients (18 females, 42 males), the median was 58 (range: 27 to 75) years. Seventeen patients were p16-positive, and 43 patients were p16-negative. Comparison of p16-positive and p16-negative groups according to age, sex, T-stage, tumor subsite, tumor profundity, lymphovascular invasion, perineural invasion and survival was not statistically significant (p>0.05). We found statistical difference between two groups according to tumor recurrence, smoking habit, and the degree of keratinization. <br> <b>Conclusion: </b> In patients who underwent surgical treatment after the diagnosis of zOC/OP-SCC, p16 positivity may have a predictive role in terms of tumor recurrence. <br> <br> </p>}, number={1}, publisher={AVES YAYINCILIK}