TY  - JOUR
T1  - The effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats
AU  - Orhan, Erkan
AU  - Yüzbaşıoğlu, Merve
AU  - Erol, Yağmur Reyyan
AU  - Bilensoy, Erem
AU  - Erdoğar, Nazlı
AU  - Demirezer, Lütfiye  Ömür
AU  - Kuruüzüm-uz, Ayşe
PY  - 2018
DA  - July
Y2  - 2017
DO  - 10.18621/eurj.335550
JF  - The European Research Journal
JO  - Eur Res J
PB  - Prusa Medical Publishing
WT  - DergiPark
SN  - 2149-3189
SP  - 152
EP  - 156
VL  - 4
IS  - 3
LA  - en
AB  - Objectives. One of the important causes of flaplosses is ischemia-reperfusion damage. Arnebia species arerich in naphthoquinone derivatives which known to have anti-inflammatory and anti-oxidanteffects. The aim of the present study was to investigate the effects of Arnebia purpurea extract on viability ofthe skin flaps. Methods. Eighteen Wistar rats were divided in three groups. Caudal-based9×3 cm size skin flap were applied ondorsum of the all rats and following surgery, 2 cc of A. purpurea extract topically was applied to the group 1 and 2 ccof 0.2% Nitrofurazon cream topically was applied to the group 2, daily. The Group 3 onlyreceived flap surgery (control group). Seven days later, all subjects were euthanatizedand necrosis rate in their flaps was calculated and compared to each other. Results.The necrosis rate wascalculated as 20.25% ± 1.59% in Group 1, 32.05% ± 2.23%in the Group 2and 37.33% ± 4.12% in the Group 3. It was found thatnecrosis rate in the Group 1 was statistically significantly less than Groups 2and 3 (p < 0.001) and thatdifference in necrosis rate between Group 2 and Group 3 was not statisticallysignificant (p > 0.05). Conclusion.Necrosis of skin flaps was reduced through topical application of A. purpurea extract.
KW  - Arnebia purpurea
KW  - skin flaps
KW  - necrosis
KW  - naphthoquinones
KW  - plant extracts
CR  - [1] Orhan E, Erol YR, Deren O, Altun S, Unal S, Erdoğan B. Efficacy of liposuction as a delay method for improving flap survival. Aesthetic Plast Surg 2016;40:931-7.
CR  - [2] Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol 2012;298:229-317.
CR  - [3] de Lima Silva JJ, Guimaraes SB, da Silveira ER, de Vasconcelos PR, Lima GG, Torres SM, et al. Effects of Copaifera langsdorffii Desf. on ischemia-reperfusion of randomized skin flaps in rats. Aesthetic Plast Surg 2009;33:104-9.
CR  - [4] van den Heuvel MG, Buurman WA, Bast A, van der Hulst RR. Review: Ischaemia-reperfusion injury in flap surgery. J Plast Reconstr Aesthet Surg 2009;62:721-6.
CR  - [5] Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004;67:2141-53.
CR  - [6] Kourounakis AP, Assimopoulou AN, Papageorgiou VP, Gavalas A, Kourounakis PN. Alkannin and shikonin: effect on free radical processes and on inflammation-a preliminary pharmacochemical investigation. Arch Pharm (Weinheim) 2002;335:262-6.
CR  - [7] Kırımer N, Bozan B, Baser KHC. A new naphthaquinone from the roots of Arnebia densiflora. Fitoterapia 1995;66:499-500.
CR  - [8] Hu Y, Jiang Z, Leung KSY, Zhao Z. Simultaneous determination of naphtaquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography. Anal Chim Acta 2006;577:26-31.
CR  - [9] Akkol EK, Koca U, Peşin I, Yilmazer D, Toker G, Yeşilada E. Exploring the wound healing activity of A. densiflora (Nordm.) Ledeb. by in vivo models. J Ethnopharmacol 2009;124:137-41.
CR  - [10] Parray JA, Hamid R, Kamili AN, Shameem N, Jan S, Ganai BA. Biological efficacy and radical scavenging potential of shikonin in Arnebia benthamii (Wall ex. G Don) Johnston. Ind Crops Prod 2015;74:434-39.
CR  - [11] Singh LK, Maheshwari DK, Shukla S. Antibacterial effect of butyryl alkannin from Arnebia euchroma against vancomycin-resistant pathogens of Enterococcus faecalis causing urinary tract infections. Nat Prod Res 2015; 29:2299-301.
CR  - [12] Zhang ZL, Fan HY, Yang MY, Zhang ZK, Liu K. Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis. World J Gastroenterol 2014;20:15310-8.
CR  - [13] Jang SY, Jang EH, Jeong SY, Kim J-H. Shikonin inhibits the growth of human prostate cancer cells via modulation of the androgen receptor. Int J Oncol 2014;44:1455-60.
CR  - [14] Yuzbasioglu M, Kuruuzum-Uz A, Guvenalp Z, Simon A, Toth G, Harput US, et al. Cytotoxic compounds from endemic Arnebia purpurea. Nat Prod Commun 2015;10:595-6.
CR  - [15] Acartürk TO, Dinçyürek H, Dağlıoğlu K. Delay by staged elevation of flaps and importance of inclusion of the perforator artery. J Hand Microsurg 2015;7:1-5.
CR  - [16] Uysal AC, Mizuno H, Tobita M, Ogawa R, Hyakusoku H. The effect of adipose-derived stem cells on ischemia-reperfusion injury: immunohistochemical and ultrastructural evaluation. Plast Reconstr Surg 2009;124:804-15.
CR  - [17] Wang ZH, Liu T, Gan L, Wang T, Yuan X, Zhang B, et al. Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol 2010;643:211-7.
CR  - [18] Rohrich RJ, Cherry GW, Spira M. Enhancement of skin-flap survival using nitroglycerin ointment. Plast Reconstr Surg 1984;73:943-8.
UR  - https://doi.org/10.18621/eurj.335550
L1  - https://dergipark.org.tr/en/download/article-file/393702
ER  -