TY  - JOUR
TT  - The Protective Effect of Iloprost and Low-Dose Methotrexate on Testicular Ischemia/Reperfusion Injury in an Experimental Model
AU  - Yuvanç, Ercan
AU  - Tuğlu, Devrim
AU  - Kısa, Üçler
AU  - Bozdoğan, Önder
AU  - Batislam, Ertan
AU  - Yılmaz, Erdal
PY  - 2017
DA  - December
DO  - 10.24938/kutfd.336398
JF  - The Journal of Kırıkkale University Faculty of Medicine
JO  - Kırıkkale Uni Med J
PB  - Kirikkale University
WT  - DergiPark
SN  - 2148-9645
SP  - 131
EP  - 138
VL  - 19
IS  - 3
KW  - Testis torsiyonu
KW  - detorsiyon
KW  - antioksidan
KW  - iskemi/reperfüzyon
KW  - iloprost
KW  - düşük doz metotreksat
N2  - Objective:To investigate the protective effects of iloprost andlow-dose methotrexate on ischemia/reperfusion (I/R) injury in surgicallydetorsed testicular torsion.Material and Methods: Rats were randomly divided into 4 groups: Group 1 (sham),Group 2: Only testicular I/R; Group 3: I/R+iloprost (10 μg/kg) and Group 4:I/R+low dose metotrexate (6 mg/kg). Torsion / ischemia and detorsion /reperfusion times were determined as 4 hours. Medications were givenintraperitoneally at 3 hours following onset of testicular torsion. Detorsionedright testises were removed 8 hours after the begining of the procedure in all4 groups.Results: In our study, we found that administration of iloprost andmetotrexate significantly increased total antioxidant capacity (TAC) whilereducing total oxidant statüs (TOS) and oxidative stress index (OSI) levelssignificantly. No statistically significant difference was found for testiclesin I/R groups according to the Johnsen scoring system.Conclusion: Admnistration of iloprost and low dose methotrexate treatmentincreased antioxidant activity in testicular samples while suppressing oxidantactivity. However, there was no change in histopathological examination andspermatogenesis scores.
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UR  - https://doi.org/10.24938/kutfd.336398
L1  - https://dergipark.org.tr/en/download/article-file/386440
ER  -