TY  - JOUR
TT  - Analysis of Time-Dependent Alteration of HIF-2α Expression in Breast Cancer Cells
AU  - Dükel, Muzaffer
AU  - Brown, Kevin D.
PY  - 2017
DA  - December
Y2  - 2017
DO  - 10.29048/makufebed.336876
JF  - Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü Dergisi
JO  - MAKUFEBED
PB  - Burdur Mehmet Akif Ersoy University
WT  - DergiPark
SN  - 1309-2243
SP  - 245
EP  - 251
VL  - 8
IS  - Ek (Suppl.) 1
KW  - Meme kanseri
KW  - hipoksiya
KW  - HIF-2a
N2  - Breast cancer is themost commonly diagnoised cancer type in women and the number of cases observedin Turkey has increased day by day. In many types of cancer including breastcancer, tumor tissues are exposed to oxygen deficiency while growing in areasdistant from blood vessels. Against this condition, knew as hypoxia, tissues respondvia increasing the expression of transcription factors called Hypoxia induciblefactor (HIF). By the effect of HIF transcription factors, cancer cells migrateto different tissues and organs by stimulating vascular development. Therefore,it is important to know the change of HIF transcription factors in hypoxiaprocess. HIF-2αis a transcription factor, which is over expressed during hypoxic conditionsand have varies the level of expression in different cancer types. The aim ofthis study is that to investigate the effect of time dependent hypoxia exposureon HIF-2α expression in different breast cancer cells and normalbreast epithelial cells.
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UR  - https://doi.org/10.29048/makufebed.336876
L1  - https://dergipark.org.tr/en/download/article-file/368674
ER  -