@article{article_337091, title={Morphological changes of the temporal lobe structures in schizophrenia and their link to the clinical symptoms regarding the gender difference and asymmetry}, journal={Deneysel ve Klinik Tıp Dergisi}, volume={34}, pages={99–110}, year={2017}, author={Elfaki, Amani and Ali, Tahir Osman and Elsheikh, Abdelgani and Erkan, Ibrahim and Güdek, Meltem Acar and Golpınar, Murat and Sahin, Bunyamin}, keywords={Automatic brain segmentation,Magnetic resonance imaging,Positive and negative syndrome scale,Schizophrenia,Temporal lobe}, abstract={<p> <br> </p> <p> <br> </p> <p> <br> </p> <p> <br> </p> <p>Temporal lobe dysfunction leads to a model of the cognitive impairments in </p> <p>schizophrenia. The aim of this study was to evaluate changes in grey and white </p> <p>matter volume, cortical area and cortical thickness of the temporal lobe in </p> <p>schizophrenic patients and to explore the functional significance of these changes </p> <p>through correlation with clinical symptoms of patients as measured with the </p> <p>positive and negative syndrome scale. 88 control subjects and 57 chronic schizophrenics </p> <p>were participated in the study. Structural magnetic resonance imaging </p> <p>was performed and the DICOM images were evaluated using automatic brain </p> <p>segmentation software (BrainSuite). The volume and volume fraction of the region </p> <p>of interest were evaluated. The mean volume of temporal lobe was smaller </p> <p>in the schizophrenics (154.20±16.49 cm3) than that of controls (174.85±17.70 </p> <p>cm3), (p≤0.05). Mean volumes of the temporal grey and temporal white matter </p> <p>in schizophrenics (110.41±12.25 cm3 and 43.81±4.96 cm3) were smaller </p> <p>than that of controls (124.14±13.15 cm3 and 50.71±6.29 cm3), (p≤0.05). The </p> <p>mean cortical area pial in schizophrenics (425.8±40.95 cm2) was smaller than </p> <p>that of control (462.30±44.42 cm2), (p≤0.05), while no differences found between </p> <p>schizophrenics and controls related to the thickness of the temporal lobe </p> <p>(p>0.05). The male patients tend to have positive correlation between the volumes </p> <p>and the positive symptoms. The present study suggests that patients with </p> <p>schizophrenia have a generalized temporal deficit. Surface area of the temporal </p> <p>lobe was smaller in the schizophrenics both for males and females. However, </p> <p>the cortex was proportionally thinner in the male schizophrenics. Positive correlations </p> <p>were observed between the volume and positive symptoms more in the </p> <p>male patients. Finally, there was no asymmetry in the volume of temporal lobe. </p>}, number={2}, publisher={Ondokuz Mayıs University}