@article{article_340047, title={BIOLOGICAL ACTIVITY STUDIES OF SOME SYNTHESIZED NOVEL FURAN AND PYRAN DERIVATIVES}, journal={Gazi University Journal of Science}, volume={30}, pages={49–55}, year={2017}, author={Sari, Esma and Aslan, Hakan and Dadı, Şeyma and Öktemer, Atilla and Loğoğlu, Elif}, keywords={Antibacterial Activity,Antifungal Activity,Furan,Pyran}, abstract={<p> <font color="#000000" face="Times New Roman" size="3"> </font> <font color="#000000"> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;">In this study, some
novel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5
dihydrofuran-3-il]ethanone (1); <span>  </span>1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone
(2); <span>  </span>Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate
(3); <span>  </span>Ethyl
4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4); <span>  </span>Ethyl
4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl
5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesized
as mentioned in our previous report </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;"> <span>[1] </span> </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;">. </span> </font> </p> <p> <font color="#000000" face="Times New Roman" size="3"> </font> <font color="#000000" face="Times New Roman" size="3"> <br /> </font> </p> <p style="margin:0cm 0cm 0pt;text-align:justify;line-height:200%;"> <font color="#000000"> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;">The in vitro novel
furan and pyran derivatives were investigated for antibacterial activity
against gram-positive bacteria i.e. <i>Bacillus licheniformis </i>M30 , <i>Bacillus
megaterium </i> M22, <i>Bacillus circulans </i> M34, <i>Bacillus subtilis </i> B1
, <i>Bacillus subtilis </i> M33 , <i>Bacillus cereus </i> B9, <span>  </span> <i>Staphylococcus aureus </i> ATCC 653, <span>  </span> <i>Micrococcus luteus </i> M3 and gram-negative
i.e. <i>Escherichia coli </i> ATCC 25922 <i>, </i> <span>and as a fungus <i> <span>  </span>Pseudomonas
aeruginosa </i> </span> P7. The antibacterial <span>  </span>and antifungal activities were determined by
the disc diffusion method (DISC) and minimum inhibition concentration (MIC)
against the tested gram-positive and gram-negative bacteria and fungus. The
inhibition zones were compared with those of reference discs which were studied
in our previous work </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;"> <span>[2] </span> </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;">. Reference discs used for control were as follows
ketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, and
gentamicin. From the results it could be said that some of the chemical
compound can be used as a raw medicine sources. </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:10pt;"> <span>  </span> </span> <span style="line-height:200%;font-family:’Times New Roman’, serif;font-size:12pt;">Their antibiogram tests showed better results than some known
antibiotics. </span> </font> </p> <p> <font color="#000000" face="Times New Roman" size="3"> </font> <br /> </p>}, number={4}, publisher={Gazi University}