TY  - JOUR
TT  - BIOLOGICAL ACTIVITY STUDIES OF SOME SYNTHESIZED NOVEL FURAN AND PYRAN DERIVATIVES
AU  - Sari, Esma
AU  - Aslan, Hakan
AU  - Dadı, Şeyma
AU  - Öktemer, Atilla
AU  - Loğoğlu, Elif
PY  - 2017
DA  - December
JF  - Gazi University Journal of Science
PB  - Gazi University
WT  - DergiPark
SN  - 2147-1762
SP  - 49
EP  - 55
VL  - 30
IS  - 4
KW  - Antibacterial Activity
KW  - Antifungal Activity
KW  - Furan
KW  - Pyran
N2  - In this study, somenovel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5dihydrofuran-3-il]ethanone (1);1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone(2); Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate(3); Ethyl4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4); Ethyl4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesizedas mentioned in our previous report [1].The in vitro novelfuran and pyran derivatives were investigated for antibacterial activityagainst gram-positive bacteria i.e. Bacillus licheniformis M30 , Bacillusmegaterium M22, Bacillus circulans M34, Bacillus subtilis B1, Bacillus subtilis M33 , Bacillus cereus B9, Staphylococcus aureus ATCC 653, Micrococcus luteus M3 and gram-negativei.e. Escherichia coli ATCC 25922 , and as a fungus Pseudomonasaeruginosa P7. The antibacterial and antifungal activities were determined bythe disc diffusion method (DISC) and minimum inhibition concentration (MIC)against the tested gram-positive and gram-negative bacteria and fungus. Theinhibition zones were compared with those of reference discs which were studiedin our previous work [2]. Reference discs used for control were as followsketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, andgentamicin. From the results it could be said that some of the chemicalcompound can be used as a raw medicine sources. Their antibiogram tests showed better results than some knownantibiotics.
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UR  - https://dergipark.org.tr/en/pub/gujs/issue//340047
L1  - https://dergipark.org.tr/en/download/article-file/380272
ER  -