@article{article_342720, title={CHEMOMETRIC ANALYSIS OF MOXIFLOXACIN AND METRONIDAZOLE IN BINARY DRUG COMBINATIONS WITH SPECTROPHOTOMETRIC METHOD}, journal={Eastern Anatolian Journal of Science}, volume={3}, pages={30–37}, year={2017}, author={Pekcan Ertokuş, Güzide and Çelik, ÜMİT MURAT}, keywords={Metronidazole and moxifloxacin,PLS}, abstract={<span class="IEEEAbstractHeadingChar"> <span style="font-size:9pt;font-family:’Times New Roman’, serif;">  </span> </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">In this study,
sensitive and accurate spectrophotometric-chemometric methods were developed
for </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">metronidazole and moxifloxacin without any
separation step </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au"> in pharmaceutical tablets. The examined Alzheimer’s drugs are donepezil
and rivastigmine. The used chemometric methods are partial least squares
regression (PLS) and principal component regression (PCR). PLS and PCR were
successfully applied for chemometric analysis of </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">metronidazole and moxifloxacin </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">in synthetic mixtures and pharmaceutical tablets. A
concentration set including binary mixtures of </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">metronidazole and moxifloxacin </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">formed to 24 different combinations were randomly
prepared in 0.1 M HCl. The accuracy and precision of the developed method were
validated by analyzing synthetic mixtures containing the examined drugs. As a
result of the determination, high recoveries and low standard deviations were
found. Absorbance and concentration values were used in Minitab and other
chemometric programs to calculate estimated concentrations with PCR and PLS.  The second step, in drug tablets (Avelox and
Flagy), was calculated amounts for </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">metronidazole
and moxifloxacin </span> <span lang="en-au" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-au">. </span>}, number={2}, publisher={Ağrı İbrahim Çeçen University}