@article{article_346968, title={The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity}, journal={The European Research Journal}, volume={4}, pages={106–111}, year={2018}, DOI={10.18621/eurj.346968}, url={https://izlik.org/JA78DY39XE}, author={Sargın, Betül and Akbal, Ayla and Resorlu, Hatice and Savaş, Yılmaz and Zateri, Coşkun and Sılan, Fatma and Özdemir, Öztürk}, keywords={Ankylosing spondylitis,disease activity,mutation,polymorphism,toll-like receptor 4}, abstract={<p class="Default" style="text-align:justify;line-height:200%;"> <b> <i> <span style="font-family:’Times New Roman’, serif;font-size:14px;">Objectives. </span> </i> </b> <b> <span style="font-family:’Times New Roman’, serif;font-size:14px;"> </span> </b> <span style="font-family:’Times New Roman’, serif;font-size:14px;">We aimed to evaluate the frequency of </span> <span lang="en-us" style="font-family:’Times New Roman’, serif;font-size:14px;" xml:lang="en-us">toll-like
receptor 4 ( </span> <span style="font-family:’Times New Roman’, serif;font-size:14px;">TLR4) gene polymorphism and its relationship between disease
activity in patients with ankylosing spondylitis (AS). </span> <b> <i> <span style="font-family:’Times New Roman’, serif;font-size:14px;">Methods. </span> </i> </b> <span style="font-family:’Times New Roman’, serif;font-size:14px;"> Forty-one AS patients (25 male/16
female) fullfilling the 1984 Modified New York Criteria and </span> <span style="font-family:’Times New Roman’, serif;font-size:14px;">41 </span> <span style="font-family:’Times New Roman’, serif;font-size:14px;">healthy
controls ( </span> <span style="font-family:’Times New Roman’, serif;"> <span style="font-size:14px;">25 male/16
female) were included in this study. Disease activity of the AS patients was
assesed by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). </span> <span style="font-size:14px;">The TLR4 gene </span> <span style="font-size:14px;">polymorphism </span> <span style="font-size:14px;"> of AS patients and healthy controls were analyzed by
Real-Time Polymerase Chain Reaction (PCR) System. </span> </span> <b> <i> <span style="font-family:’Times New Roman’, serif;font-size:14px;">Results. </span> </i> </b> <span style="font-family:’Times New Roman’, serif;"> <span style="font-size:14px;">
Three (7.3%) patients with AS had TLR4 gene polymorphism compared with healthy
controls (0/41; 0%). Two of these patients had heterozygous mutation and one
had homozygous mutation. Significant correlation was not found between TLR4
gene polymorphism and BASDAI score ( </span> <i> <span style="font-size:14px;">p </span> </i> <span style="font-size:14px;">
> 0.05). </span> </span> <span style="font-family:’Times New Roman’, serif;font-size:14px;"> </span> <b> <i> <span style="font-family:’Times New Roman’, serif;font-size:14px;">Conclusions. </span> </i> </b> <b> <span style="font-family:’Times New Roman’, serif;font-size:14px;"> </span> </b> <span style="font-family:’Times New Roman’, serif;"> <span style="font-size:14px;">In our study, TLR4
gene polymorphism was higher in patients with AS compared with control group. But,
this polymorphism was not associated with disease activity, </span> <span style="font-size:14px;">erythrocyte sedimentation rate and C-reactive protein
levels. </span> </span> <span style="font-size:14px;"> </span> <span style="font-family:’Times New Roman’, serif;"> </span> </p> <p> </p> <p> </p>}, number={2}