@article{article_357250, title={Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood}, journal={Marmara Medical Journal}, volume={30}, pages={169–176}, year={2017}, DOI={10.5472/marumj.357250}, author={Batırel, Saime and Buyukuslu, Nihal and Bekıroglu, Nural and Garıpagaoglu, Muazzez}, keywords={Leptin,Fatty acids,Cord blood,Newborn,Pregnancy}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objectives: </span> </b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Maternal intake of n-3 long chain polyunsaturated fatty
acids (LC-PUFAs) has positive effects on fetal development and pregnancy
outcomes. Leptin plays  an important  role in placental transportation of LC-PUFAs. In
this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on
anthropometric parameters of mother and newborn,  the levels of fatty acids (FAs)  and leptin in cord blood. <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">        
Material and Methods: </span> </b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> Thirty-one
pregnant women were included. Eighteen were assigned to the control group and
13 received a supplement containing n-3 </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">LC-PUFAs during last trimester of gestation ( </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">supplemented group). </span> <b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Physical examinations of
the participants were performed and additional data were collected with a </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> questionnaire. </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> FAs and leptin
concentrations in  cord blood samples
were analyzed using </span> <span class="st1"> <span style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;">gas chromatography-mass
spectrometry <span style="color:#545454;"> ( </span> </span> </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">GC-MS) and </span> <span class="st1"> <span style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;color:#545454;">enzyme-linked </span> </span> <span class="st1"> <span style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;">immunosorbent
assay </span> </span> <span style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;"> <span lang="en-us" xml:lang="en-us">(ELISA) kit respectively. </span> </span> <b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </b> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">         Results: </span> </b> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> A total amount of n-3 PUFAs  significantly increased after treatment.  n-6/n-3 PUFAs ratios and </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> leptin levels </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">were lower in the supplemented group ( <i>P </i>=0.052, </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <i>P </i>=0.140 </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">
respectively </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">) </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">. </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">There were
positive correlations between leptin levels and the z scores for birth weight,
height and head circumference of the newborns in the control group. The
supplementation affected leptin concentration 
to be positively correlated  with
n-6/n-3 PUFA ratios. </span> <span lang="en-us" style="font-size:11pt;line-height:200%;font-family:’Times New Roman’, se}, number={3}, publisher={Marmara University}