@article{article_370641, title={Burn-induced distant organ injury in rats and the effect of minocycline}, journal={Marmara Medical Journal}, volume={30}, pages={137–145}, year={2017}, DOI={10.5472/marumj.370641}, author={Bahadır, Elif and Sancar, Murat and Tarhan, Gazi Giray and Koçak, Emre and Budancamanak, Zeynep and Karaaslan, Seda and Kervancıoğlu Demirci, Elif and Yüksel, Meral and Ercan, Feriha and Alican, İnci}, keywords={Burn,Kidney,Liver,Minocycline,Rat}, abstract={<p>Objectives: This study aimed to examine the anti-inflammatory </p> <p>potential of orally-administered minocycline, a semi-synthetic </p> <p>second-generation tetracycline, on burn-induced liver and kidney </p> <p>damage in rats. </p> <p>Materials and Methods: Female Sprague-Dawley rats (250- </p> <p>300 g; n=7-8/group) were used. Burn and sham groups were </p> <p>exposed to 90 0C and 25 0C water bath for 10 s, respectively. </p> <p>Minocycline (20 mg/kg; twice daily; orogastrically) was </p> <p>administered for 24 h post-burn. After decapitation, trunk blood </p> <p>was collected for biochemical assays. Liver and kidneys were </p> <p>excised for histopathological evaluation and malondialdehyde </p> <p>(MDA), glutathione and chemiluminescence (CL) assays. </p> <p>Results: Minocycline treatment did not exert a significant effect </p> <p>on serum alanine aminotransferase, aspartate aminotransferase, </p> <p>blood urea nitrogen, and creatinine levels of the burn group. </p> <p>Increased serum total oxidant status of the burn group was reversed </p> <p>(P<0.001) and liver microscopic lesion score showed a slight </p> <p>reduction (P<0.01) by minocycline. Minocycline did not cause a </p> <p>significant effect on increased tissue MDA and glutathione levels </p> <p>of the burn group but reversed the elevated luminol CL levels </p> <p>(P<0.001, for liver and P<0.01, for kidney, respectively). </p> <p>Conclusion: Minocycline treatment to rats for 24 h post-burn </p> <p>was found to be effective to reduce oxidant production in the liver </p> <p>and kidney; however, it showed slight protection on these tissues </p> <p>against oxidant damage. </p>}, number={3}, publisher={Marmara University}