TY  - JOUR
TT  - Burn-induced distant organ injury in rats and the effect of minocycline
AU  - Bahadır, Elif
AU  - Sancar, Murat
AU  - Tarhan, Gazi Giray
AU  - Koçak, Emre
AU  - Budancamanak, Zeynep
AU  - Karaaslan, Seda
AU  - Kervancıoğlu Demirci, Elif
AU  - Yüksel, Meral
AU  - Ercan, Feriha
AU  - Alican, İnci
PY  - 2017
DA  - October
DO  - 10.5472/marumj.370641
JF  - Marmara Medical Journal
JO  - Marmara Med J
PB  - Marmara University
WT  - DergiPark
SN  - 1019-1941
SP  - 137
EP  - 145
VL  - 30
IS  - 3
KW  - Böbrek
KW  - Karaciğer
KW  - Minosiklin
KW  - Sıçan
KW  - Yanık
N2  - Objectives: This study aimed to examine the anti-inflammatorypotential of orally-administered minocycline, a semi-syntheticsecond-generation tetracycline, on burn-induced liver and kidneydamage in rats.Materials and Methods: Female Sprague-Dawley rats (250-300 g; n=7-8/group) were used. Burn and sham groups wereexposed to 90 0C and 25 0C water bath for 10 s, respectively.Minocycline (20 mg/kg; twice daily; orogastrically) wasadministered for 24 h post-burn. After decapitation, trunk bloodwas collected for biochemical assays. Liver and kidneys wereexcised for histopathological evaluation and malondialdehyde(MDA), glutathione and chemiluminescence (CL) assays.Results: Minocycline treatment did not exert a significant effecton serum alanine aminotransferase, aspartate aminotransferase,blood urea nitrogen, and creatinine levels of the burn group.Increased serum total oxidant status of the burn group was reversed(P<0.001) and liver microscopic lesion score showed a slightreduction (P<0.01) by minocycline. Minocycline did not cause asignificant effect on increased tissue MDA and glutathione levelsof the burn group but reversed the elevated luminol CL levels(P<0.001, for liver and P<0.01, for kidney, respectively).Conclusion: Minocycline treatment to rats for 24 h post-burnwas found to be effective to reduce oxidant production in the liverand kidney; however, it showed slight protection on these tissuesagainst oxidant damage.
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UR  - https://doi.org/10.5472/marumj.370641
L1  - https://dergipark.org.tr/en/download/article-file/408831
ER  -