@article{article_377767, title={Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro}, journal={International Journal of Secondary Metabolite}, volume={4}, pages={512–516}, year={2017}, DOI={10.21448/ijsm.377767}, url={https://izlik.org/JA56GB75GH}, author={Erenler, Ramazan and Demirtas, İbrahim and Karan, Tunay and Altun, Muhammed and Gul, Fatih}, keywords={Kickxia spuria, flavone, HeLa}, abstract={<p style="text-align:justify;"> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Natural
products derived from plants play a significant role in drug discovery due to
the revealing a large variety of pharmaceutical effects. <i>Kickxia spuria </i>was collected from Bingol, Turkey. Aerial parts of
the plant were boiled in water for 2 h then extracted with ethyl acetate. After
evaporation of the solvent by rotary evaporator, the extract was subjected to
column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by
spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative
activity of isolated compound was tested against HeLa (human cervix carcinoma)
cell lines by xCELLigence assay, and found out that the compound exhibited
excellent activity. </span> <br /> </p>}, number={3, Special Issue 2}