TY  - JOUR
T1  - Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro
TT  - Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro
AU  - Erenler, Ramazan
AU  - Demirtas, İbrahim
AU  - Karan, Tunay
AU  - Altun, Muhammed
AU  - Gul, Fatih
PY  - 2017
DA  - December
DO  - 10.21448/ijsm.377767
JF  - International Journal of Secondary Metabolite
JO  - Int. J. Sec. Metabolite
PB  - İzzet KARA
WT  - DergiPark
SN  - 2148-6905
SP  - 512
EP  - 516
VL  - 4
IS  - 3, Special Issue 2
LA  - en
AB  - Naturalproducts derived from plants play a significant role in drug discovery due tothe revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts ofthe plant were boiled in water for 2 h then extracted with ethyl acetate. Afterevaporation of the solvent by rotary evaporator, the extract was subjected tocolumn chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone byspectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferativeactivity of isolated compound was tested against HeLa (human cervix carcinoma)cell lines by xCELLigence assay, and found out that the compound exhibitedexcellent activity.
KW  - Kickxia spuria
KW  - flavone
KW  - HeLa
N2  - Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
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UR  - https://doi.org/10.21448/ijsm.377767
L1  - https://dergipark.org.tr/en/download/article-file/403047
ER  -