TY  - JOUR
TT  - Investigation of of Interaction Mechanisms of Enviromental Factors on Inflammatory Bowel Disease Development
AU  - Zeybek, Şakir Ümit
AU  - Çevik, Aydın
AU  - Timirci Kahraman, Özlem
AU  - Çelik, Faruk
AU  - Çelik, Burcu
AU  - Çetiner, Gökçe
AU  - Ergen, H. Arzu
AU  - Çakmakoğlu, Bedia
PY  - 2017
DA  - December
JF  - Deneysel Tıp Araştırma Enstitüsü Dergisi
PB  - Istanbul University
WT  - DergiPark
SN  - 2630-6050
SP  - 34
EP  - 38
VL  - 7
IS  - 14
KW  - inflamatuar barsak hastalığı
KW  - leptin
KW  - ghrelin
KW  - rezistin
KW  - EGF
KW  - TNF-α
KW  - ELISA
N2  - Inflammatuary Bowel Disease ( IBD) is a disease reported that occurs from environmental, infectious, genetic and autoimmune factors. In IBD, there is a lack of self-protection of intestinal mucosa against luminal changes. Chronic inflammation is a hallmark of this disease. The most common age ranges are between 15-25 and 55-65. Adipose tissue and the elements of it, provides the secretion of many proteins (adipocytokines) and thus, regulation of the biologic functions like metabolism and inflammation. Leptin affects energy levels and neuroendocrine functions of spesific hypothalamic pathways primarily. But molecular means of leptin resistance is not understood enough yet. Ghrelin is known as ligand of ghrelin hormone’s endogenous receptor. It increases calcium concentrations by binding specific receptors. It leads to secretion of growth hormone and thus has many physiological effects.Recently discovered resistin, is a hormone secreted by fat cells. It is recognized as a peripheric signal molecule and the status of risk about IBD is being investigated in recent years. The effect of Tumor necrosis factor-alpha (TNF-α), known as a cytokine which is playing a role in potential lethal inflammation, is under investigation in human and it is reported that TNF-α especially plays a critical role in IBD pathogenesis. Epidermal growth factor (EGF) is a multipotent peptide that promotes epithelial growth, gastric acid secretion and angiogenesis. In some studies, EGF is indicated that it is one of the markers affecting mucosa’s susceptibility to damage and tissue repair in IBD.The data belongs to our research are corelated with the literatures. Studying of leptin, ghelin, resistin, EGF and TNF-α markers will be studied together for the first time and as a panel.
CR  - 1) Jahanshahi G, Motavasel V, Rezaie A, Hashtroudi AA, Daryani NE, Abdollahi M. Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases. Dig Dis Sci. 2004 Nov-Dec;49(11-12):1752-7.
CR  - 2) Oikonomou KA, Kapsoritakis AN, Kapsoritaki AI, Manolakis AC, Tsiopoulos FD, Germenis AE, Potamianos SP. Downregulation of serum epidermal growth factor in patients with inflammatory bowel disease. Is there a link with mucosal damage? Growth Factors. 2010 Dec;28(6):461-6.
CR  - 3) Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA.
CR  - Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease.
CR  - Swiss Med Wkly. 2009 May 16;139(19-20):278-87.
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CR  - 5) Komatsu M, Kobayashi D, Saito K, Furuya D, Yagihashi A, Araake H, Tsuji N, Sakamaki S, Niitsu Y, Watanabe N.Tumor necrosis factor-alpha in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR. Clin Chem. 2001;47(7):1297-301.
CR  - 6)Konstantinos Karmiris, Ioannis E. Koutroubakis, Elias A. Kouroumalis, Leptin, adiponectin, resistin, and ghrelin – Implications for inflammatory bowel disease. Mol Nutr Food Res. 2008 Aug;52(8):855-66.
UR  - https://dergipark.org.tr/en/pub/iudtaed/issue//379341
L1  - https://dergipark.org.tr/en/download/article-file/405135
ER  -