TY  - JOUR
TT  - Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac
AU  - Malı, Kailas Krishnat
AU  - C Dhawale, Shashikant
AU  - J Dıas, Remeth
AU  - D Havaldar, Vijay
AU  - R Kavıtake, Pankaj
PY  - 2017
DA  - December
JF  - Marmara Pharmaceutical Journal
JO  - J Res Pharm
PB  - Marmara University
WT  - DergiPark
SN  - 1309-0801
SP  - 771
EP  - 782
VL  - 21
IS  - 4
KW  - Interpenetrating networks
KW  - carboxymethyl tamarind gum
KW  - chitosan
KW  - aceclofenac
KW  - crosslinking
N2  - The aim of present investigation was to characterizecarboxymethyl tamarind gum (CMTG) based interpenetratingnetworks (IPNs) of aceclofenac for site specific sustained delivery.The drug loaded IPNs were prepared by using chitosan andCMTG as polymers and gluteraldehyde as crosslinking agent.The IPNs were characterized by Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermalanalysis, X-ray powder diffraction and solid state 13C-nuclearmagnetic resonance spectroscopy. The prepared IPNs wereevaluated for the drug entrapment efficiency and equilibriumswelling. The drug release from IPNs was studied in 0.1NHClfor 2h followed by phosphate buffer pH 6.8 for further 10h andcompared with commercial tablet. The results of ATR-FTIRand thermal analysis for blank IPNs indicated intercalationof polymeric chains of crosslinked CMTG and chitosan.The results of solid state characterization revealed that theaceclofenac is compatible with IPNs. Entrapment efficiency ofIPNs was found to be increased with increase in crosslinkerconcentration as well as amount of CMTG. The equilibriumswelling study indicated pH dependent swelling of IPNs. Thedrug release by IPNs showed sustained release of aceclofenacupto 12h while commercial formulation showed fast releasewithin 8h. From the results, it can be concluded that the IPNsof CMTG and chitosan has potential in development of sitespecific sustained drug delivery.
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UR  - https://dergipark.org.tr/en/pub/marupj/issue//379657
L1  - https://dergipark.org.tr/en/download/article-file/405517
ER  -