TY - JOUR TT - Kanatlı Proventrikulusunda Vasküler Endotel Büyüme Faktörü ve Reseptörlerinin Dağılımı AU - Sağsöz, Hakan AU - Güney Saruhan, Berna AU - Akbalık, Mehmet Erdem AU - Topaloğlu, Uğur AU - Ketani, Muzaffer Aydın PY - 2017 DA - December Y2 - 2017 JF - Dicle Üniversitesi Veteriner Fakültesi Dergisi JO - Dicle Üniv Vet Fak Derg PB - Dicle University WT - DergiPark SN - 1307-9972 SP - 122 EP - 129 VL - 10 IS - 2 KW - chicken KW - flt1/fms KW - proventriculus KW - VEGF N2 -  Bu çalışmada kanatlı proventrikuluslarındavasküler endotelyal büyüme faktörü (VEGF) ve reseptörlerinin (flt1/fms,flk1/KDR) fizyolojik rollerini daha iyi anlamak için, immünohistokimyakullanılarak hücresel lokalizasyonları incelendi. Çalışmanın materyalini 10adet (5 erkek ve 5 dişi) tavuk oluşturdu. Proventrikulustan elde edilen dokuörnekleri rutin histolojik işlemler için % 10 formol-alkolde tespit edildi.Kanatlı proventrikuluslarında luminal ve bez epitel hücreleri, stromal ve düzkas hücreleri ile damarların endotel ve düz kas hücrelerinin VEGF vereseptörleri için pozitif immunreaksiyon gösterdiği belirlendi. Bununlabirlikte VEGF ve reseptörlerinin bez epitel hücrelerinde daha güçlü sitoplazmikbir ekspresyon gösterdiği saptandı. Sonuç olarak VEGF ve reseptörlerinin kanatlıproventrikulusundaki non-endotelyal hücrelerde çoğalma, farklılaşma, apopitozisve anjiogenezisin sağlanmasında kritik bir rolünün olabileceği düşünülmüştür. CR - 1. Nasrin M, Siddiqi MNH, Masum MA, Wares MA. (2012). Gross and Histological Studies of Digestive Tract of Broilers during Postnatal Growth and Development. J Bangladesh Agril Univ. 10 (1): 69-77. CR - 2. De Verdal H, Mignon-Grasteau S, Jeulin C, et al. (2010). 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